Impact summary
Granting of this patent is the first step to producing a flock or her level commercial product to mitigate stress and loss of productivity caused by many types of common management procedures in sheep, cattle and other production species.This patent represents the first flock or herd level treatment for mitigation of the clinical signs of perennial ryegrass toxicoses PRGT in sheep. PRGT is a significant production issue in Australia, New Zealand causing millions of dollars of stock losses and productivity a year. Alleviation of clinical signs by delivery of an affordable flock or her level treatment will provide significant economic and animal welfare benefits for cattle, sheep and dairy producers.
| Impact date | 20 Nov 2014 → 20 Nov 2034 |
|---|---|
| Category of impact | Economic Impact |
| Impact level | Benefit |
Keywords
- toxicosis
- bromide
- sheep
- cattle
- perennial ryegrass
- toxicity
- staggers
- PRGT
Countries where impact occurred
- Australia
Documents & Links
Related content
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Research Outputs
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New insights into the clinicopathological mechanisms and presentation of perennial ryegrass toxicosis in Australia
Research output: Other contribution to conference › Abstract › peer-review
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Development of a model for investigation of perennial ryegrass toxicosis in sheep
Research output: Contribution to journal › Article › peer-review
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Perennial ryegrass toxicosis: effects of the indole diterpenoid mycotoxins on movement and metabolism in a mouse model
Research output: Other contribution to conference › Poster › peer-review
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Treatment with potassium bromide mitigates ataxia and reduces tremor in lambs with perennial ryegrass toxicosis
Research output: Contribution to journal › Article › peer-review
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Timed environmental exposure indicates sample stability for reliable noninvasive measurement of fecal cortisol metabolite concentrations in sheep
Research output: Contribution to journal › Article › peer-review
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Potassium bromide mitigates clinical signs of intoxication caused by the indole diterpenoid toxin lolitrem B
Research output: Other contribution to conference › Poster › peer-review
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Tremorgenic effects and functional metabolomics analysis of lolitrem B and its biosynthetic intermediates
Research output: Contribution to journal › Article › peer-review
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Effects of the indole diterpenoid mycotoxin lolitrem B and its pathway intermediates on movement and metabolic status in a mouse model of perennial ryegrass toxicosis
Research output: Other contribution to conference › Poster › peer-review
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Evidence of dehydration and electrolyte disturbances in cases of perennial ryegrass toxicosis in Australian sheep
Research output: Contribution to journal › Article › peer-review
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A single exposure to the tremorgenic mycotoxin lolitrem B inhibits voluntary motor activity and spatial orientation but not spatial learning or memory in mice
Research output: Contribution to journal › Article › peer-review
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A functional metabolomics analysis of lolitrem B and its biosynthetic intermediates in the murine brain
Research output: Other contribution to conference › Abstract
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Pharmacokinetics of bromide in adult sheep following oral and intravenous administration
Research output: Contribution to journal › Article › peer-review
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Treatment of clinical signs of perennial rye grass toxicosis in sheep
Research output: Book/Report › Commissioned report (public)
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Activities
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Clinical and Pathological Characterisation of Perennial Ryegrass Toxicosis and Investigation of Bromide as a Therapeutic Agent.
Activity: Supervision/Examination/Mentoring › Internal HDR Supervision
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Press/Media
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New treatment hope for ryegrass staggers
Press/Media: Press / Media
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Impacts