• 3914 Citations
  • 29 h-Index
1991 …2018
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Personal profile

Research Interests

  • The biology of the skeleton, specifically the process of bone formation and the cells controlling that process, the osteoblasts.
  • The roles of specific genes in skeletal regulation and more recently, the identification and characterisation of novel genes involved in bone disease, in particular ankylosing spondylitis and osteoporosis
  • Understanding the role of genes in disease to aid in the development of new diagnostic and therapeutic approaches and the use of both genetic and gene expression profiling to develop diagnostic algorithms for skeletal disease to enable early diagnosis and optimise treatments.

Professional Information

Previous Positions Held

  • Acting Associate Dean (Research) – January 2014 - March 2015

  • Faculty of Medicine and Biomedical Research (M+BS), University of Queensland

  • Deputy Director, Education (2011-) and Head, Skeletal Biology Group (2005-)

  • University of Queensland Diamantina Institute

  • Chair, Translational Research Institute Education Committee (2013-)

  • Honorary Senior Research Fellow (2011-)

  • Mater Research

  • Senior Scientist, Target validation - October 2001 to July 2005

  • Phenogene Therapeutics/Enobia Pharma

  • Research: Developing novel bone genes as potential new therapeutics

  • Senior Research Officer - February 1996-August 2001

  • Bone and Mineral Program, Garvan Institute of Medical Research

  • Research: Characterisation of mouse models of bone disease

  • Post-doctoral Research Associate - January 1994-July 1995

  • Department of Biology, University of California, San Diego (UCSD)

  • Research: Characterisation of bone proteins

Personal profile

Associate Professor Gethin Thomas has over 20 years’ experience in research and research management across universities, research institutes and the private sector.

He undertook his undergraduate and PhD studies in the Department of Biology at the University of Birmingham in the UK, graduating with a PhD in Bone Cell Biology. He then undertook post-doctoral studies at the University of California in San Diego for two years followed by five years at the Garvan Institute. Dr Thomas then moved to industry spending five years with a biotechnology company in Montréal where he identified two novel bone genes, Ostn and Bril. Ostn being patented and targeted for drug development and Bril being identified as the gene mutated in osteogenesis imperfecta type V. In 2005, Dr Thomas returned to academia in Australia leading the Musculoskeletal Biology Group at the University of Queensland Diamantina Institute (UQDI).

In 2011, he also took on the Deputy Director of Education role at UQDI taking responsibility for the institute’s RHD student cohort, as well as sitting on faculty and university level RHD committees. Since this time he had continually developed his interest in the RHD management space doubling the size of the UQDI student cohort and establishing a number of new programs. He has extensive knowledge of the granting system having held 3 NHMRC grants as CIA as well as a number of other grants from other bodies. He has also served on grant review panels for the NHMRC, Arthritis Australia and the Rebecca Cooper Foundation as well as reviewing grants for a number of International funding bodies.

Fingerprint Dive into the research topics where Gethin Thomas is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Ankylosing Spondylitis Medicine & Life Sciences
Genes Medicine & Life Sciences
N-ethyl-N-nitrosourea Agriculture & Biology
Osteogenesis Medicine & Life Sciences
Joints Medicine & Life Sciences
Inflammation Medicine & Life Sciences
Ethylnitrosourea Medicine & Life Sciences
Spondylitis Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1991 2018

13 Citations (Scopus)

Genetic variants in ERAP1 and ERAP2 associated with immune-mediated diseases influence protein expression and the isoform profile

Hanson, A. L., Cuddihy, T., Haynes, K., Loo, D., Morton, C. J., Oppermann, U., Leo, P., Thomas, G. P., Lê Cao, K. A., Kenna, T. J. & Brown, M. A., Feb 2018, In : Arthritis and Rheumatology. 70, 2, p. 255-265 11 p.

Research output: Contribution to journalArticle

Aminopeptidases
Immune System Diseases
Protein Isoforms
Endoplasmic Reticulum
Chromosomes
3 Citations (Scopus)
3 Downloads (Pure)

Early anti-inflammatory intervention ameliorates axial disease in the proteoglycan-induced spondylitis mouse model of ankylosing spondylitis

Tseng, H. W., Glant, T. T., Brown, M. A., Kenna, T. J., Thomas, G. P. & Pettit, A. R., 30 May 2017, In : BMC Musculoskeletal Disorders. 18, 1, p. 1-9 9 p., 228.

Research output: Contribution to journalArticle

Open Access
File
Spondylitis
Ankylosing Spondylitis
Proteoglycans
Anti-Inflammatory Agents
Intervertebral Disc
9 Citations (Scopus)

Epigenetic and gene expression analysis of ankylosing spondylitis-associated loci implicate immune cells and the gut in the disease pathogenesis

Li, Z., Haynes, K., Pennisi, DJ., Anderson, LK., Song, X., Thomas, G. P., Kenna, T., Leo, P. & Brown, M. A., Jun 2017, In : Genes and Immunity. 18, 3, p. 135-143 9 p.

Research output: Contribution to journalArticle

Ankylosing Spondylitis
Epigenomics
Gene Expression
Natural Killer Cells
Monocytes
12 Citations (Scopus)

Genetic association of ankylosing spondylitis with TBX21 influences T-bet and pro-inflammatory cytokine expression in humans and SKG mice as a model of spondyloarthritis

Lau, M. C., Keith, P., Costello, M-E., Bradbury, L. A., Hollis, K. A., Thomas, R., Thomas, G. P., Brown, M. A. & Kenna, T. J., Jan 2017, In : Annals of the Rheumatic Diseases. 76, 1, p. 261-269 9 p.

Research output: Contribution to journalArticle

Ankylosing Spondylitis
Transcription Factors
Genes
Cytokines
Joint Diseases

Genetic diagnostic profiling in axial Spondyloarthritis: A real-world study

Thomas, G. P., Willner, D., Robinson, P. C., Cortes, A., Duan, R., Rudwaleit, M., Akkoc, N., Braun, J., Chou, C. T., Maksymowych, W. P., Ozgocmen, S., Roussou, E., Sieper, J., Valle-Oñate, R., van der Heijde, D., Wei, J., Leo, P., Brown, M. A. & International Genetics of Ankylosing Spondylitis Consortium, 2017, In : Clinical and Experimental Rheumatology. 35, 2, p. 229-233 5 p.

Research output: Contribution to journalArticle

Ankylosing Spondylitis
Area Under Curve
Back Pain
Referred Pain
Immune System Diseases

Press / Media