• 4154 Citations
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1991 …2018

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2018

Genetic variants in ERAP1 and ERAP2 associated with immune-mediated diseases influence protein expression and the isoform profile

Hanson, A. L., Cuddihy, T., Haynes, K., Loo, D., Morton, C. J., Oppermann, U., Leo, P., Thomas, G. P., Lê Cao, K. A., Kenna, T. J. & Brown, M. A., Feb 2018, In : Arthritis and Rheumatology. 70, 2, p. 255-265 11 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2017

Early anti-inflammatory intervention ameliorates axial disease in the proteoglycan-induced spondylitis mouse model of ankylosing spondylitis

Tseng, H. W., Glant, T. T., Brown, M. A., Kenna, T. J., Thomas, G. P. & Pettit, A. R., 30 May 2017, In : BMC Musculoskeletal Disorders. 18, 1, p. 1-9 9 p., 228.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
5 Downloads (Pure)

Epigenetic and gene expression analysis of ankylosing spondylitis-associated loci implicate immune cells and the gut in the disease pathogenesis

Li, Z., Haynes, K., Pennisi, DJ., Anderson, LK., Song, X., Thomas, G. P., Kenna, T., Leo, P. & Brown, M. A., Jun 2017, In : Genes and Immunity. 18, 3, p. 135-143 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Genetic association of ankylosing spondylitis with TBX21 influences T-bet and pro-inflammatory cytokine expression in humans and SKG mice as a model of spondyloarthritis

Lau, M. C., Keith, P., Costello, M-E., Bradbury, L. A., Hollis, K. A., Thomas, R., Thomas, G. P., Brown, M. A. & Kenna, T. J., Jan 2017, In : Annals of the Rheumatic Diseases. 76, 1, p. 261-269 9 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Genetic diagnostic profiling in axial Spondyloarthritis: A real-world study

Thomas, G. P., Willner, D., Robinson, P. C., Cortes, A., Duan, R., Rudwaleit, M., Akkoc, N., Braun, J., Chou, C. T., Maksymowych, W. P., Ozgocmen, S., Roussou, E., Sieper, J., Valle-Oñate, R., van der Heijde, D., Wei, J., Leo, P., Brown, M. A. & International Genetics of Ankylosing Spondylitis Consortium, 2017, In : Clinical and Experimental Rheumatology. 35, 2, p. 229-233 5 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2016

Inflammation-driven bone formation in a mouse model of ankylosing spondylitis: Sequential not parallel processes

Tseng, H-W., Pitt, M. E., Glant, T. T., McRae, A. F., Kenna, T. J., Brown, M. A., Pettit, A. R. & Thomas, G. P., 2016, In : Arthritis Research and Therapy. 18, 35, p. 1-12 12 p., 35.

Research output: Contribution to journalArticle

Open Access
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16 Citations (Scopus)
2 Downloads (Pure)

Mice with an N-Ethyl-N-Nitrosourea (ENU) induced Tyr209Asn mutation in natriuretic peptide receptor 3 (NPR3) provide a model for kyphosis associated with activation of the MAPK signaling pathway

Esapa, C. T., Piret, S. E., Nesbit, M. A., Loh, N. Y., Thomas, G., Croucher, P. I., Brown, M. A., Brown, S. D. M., Cox, R. D. & Thakker, R. V., 13 Dec 2016, In : PLoS One. 11, 12, p. 1-18 18 p., e0167916.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
4 Downloads (Pure)

Transgenic Adipose-specific Expression of the Nuclear Receptor RORα Drives a Striking Shift in Fat Distribution and Impairs Glycemic Control

Tuong, Z. K., Fitzsimmons, R., Wang, S. C. M., Oh, T. G., Lau, P., Steyn, F., Thomas, G. & Muscat, G. E. O., 01 Sep 2016, In : EBioMedicine. 11, p. 101-117 17 p.

Research output: Contribution to journalArticle

Open Access
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2 Citations (Scopus)
11 Downloads (Pure)
2015

Confluence-Induced Squamous Differentiation Is Not Accompanied by Changes in H3K27me3 Repressive Epigenetic Mark

Gannon, O. M., De Long, L. M., Hazar-Rethinam, M., Topkas, E., Endo-Munoz, L. B., Thomas, G. P., Zhang, P. & Saunders, N. A., 2015, In : Journal of Investigative Dermatology. 135, 10, p. 2446-2454 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Disease-associated polymorphisms in ERAP1 do not alter endoplasmic reticulum stress in patients with ankylosing spondylitis

Kenna, TJ., Lau, MC., Keith, P., Ciccia, F., Costello, ME., Bradbury, L., Low, P-L., Agrawal, N., Triolo, G., Alessandro, R., Robinson, P. C., Thomas, G. & Brown, M. A., 2015, In : Genes and Immunity. 16, 1, p. 35-42 8 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

ERAP2 functional knockout in humans does not alter surface heavy chains or HLA-B27, inflammatory cytokines or endoplasmic reticulum stress markers

Robinson, P. C., Lau, E., Keith, P., Lau, M. C., Thomas, G. P., Bradbury, L. A., Brown, M. A. & Kenna, T. J., 2015, In : Annals of the Rheumatic Diseases. 74, 11, p. 2092-2095 4 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

N-ethyl-N-Nitrosourea (ENU) induced mutations within the klotho gene lead to ectopic calcification and reduced lifespan in mouse models

Esapa, C. T., Hannan, F. M., Babinsky, V. N., Potter, P., Thomas, G. P., Croucher, P. I., Brown, M. A., Brown, S. DM., Cox, R. D. & Thakker, R. V., 2015, In : PLoS One. 10, 4, p. 1-19 19 p., e0122650.

Research output: Contribution to journalArticle

Open Access
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7 Citations (Scopus)
6 Downloads (Pure)

Quantitative gene profiling of long noncoding RNAs with targeted RNA sequencing

Clark, M. B., Mercer, T. R., Bussotti, G., Leonardi, T., Haynes, K. R., Crawford, J., Brunck, M. E., Lê Cao, K-A., Thomas, G. P., Chen, W. Y., Taft, R. J., Nielsen, L. K., Enright, A. J., Mattick, J. S. & Dinger, M. E., 2015, In : Nature Methods. 12, 4, p. 339-342 4 p.

Research output: Contribution to journalArticle

91 Citations (Scopus)

Ror alpha deficiency and decreased adiposity are associated with induction of thermogenic gene expression in subcutaneous white adipose and brown adipose tissue

Lau, P., Tuong, Z. K., Wang, S-C., Fitzsimmons, R. L., Goode, J. M., Thomas, G. P., Cowin, G. J., Pearen, M. A., Mardon, K., Stow, J. L. & Muscat, G. EO., 2015, In : American Journal of Physiology - Endocrinology and Metabolism. 308, 2, p. E159-E171 13 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Treatment of a mouse model of ankylosing spondylitis with exogenous sclerostin has no effect on disease progression

Haynes, K. R., Tseng, H-W., Kneissel, M., Glant, T. T., Brown, M. A. & Thomas, G. P., 2015, In : BMC Musculoskeletal Disorders. 16, 368, p. 1-8 8 p.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
3 Downloads (Pure)
2014

A brilliant breakthrough in OI type V

Lazarus, S., Moffatt, P., Duncan, EL. & Thomas, GP., 2014, In : Osteoporosis International. 25, 2, p. 399-405 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Addition of interleukin-6 inhibition with tocilizumab to standard graft-versus-host disease prophylaxis after allogeneic stem-cell transplantation: A phase 1/2 trial

Kennedy, G. A., Varelias, A., Vuckovic, S., Le Texier, L., Gartlan, K. H., Zhang, P., Thomas, G., Anderson, L., Boyle, G., Cloonan, N., Leach, J., Sturgeon, E., Avery, J., Olver, S. D., Lor, M., Misra, A., Hutchins, C., Morton, A. J., Durrant, S. TS., Subramoniapillai, E. & 5 others, Butler, J. P., Curley, C. I., MacDonald, K. PA., Tey, S-K. & Hill, G. R., 2014, In : The Lancet Oncology. 15, 13, p. 1451-1459 9 p.

Research output: Contribution to journalArticle

124 Citations (Scopus)

Interleukin-23 mediates the intestinal response to microbial β-1,3-glucan and the development of spondyloarthritis pathology in SKG mice

Benham, H., Rehaume, L. M., Hasnain, S. Z., Velasco, J., Baillet, A. C., Ruutu, M., Kikly, K., Wang, R., Tseng, H-W., Thomas, G. P., Brown, M. A., Strutton, G., McGuckin, M. A. & Thomas, R., 2014, In : Arthritis and Rheumatology. 66, 7, p. 1755-1767 13 p.

Research output: Contribution to journalArticle

102 Citations (Scopus)

Resveratrol does not benefit patients with nonalcoholic fatty liver disease

Chachay, V. S., Macdonald, G. A., Martin, J. H., Whitehead, J. P., O'Moore--Sullivan, T. M., Lee, P., Franklin, M., Klein, K., Taylor, P. J., Ferguson, M., Coombes, J., Thomas, G., Cowin, G. J., Kirkpatrick, C., Prins, J. B. & Hickman, I., 2014, In : Clinical Gastroenterology and Hepatology. 12, 12, p. 2092-2103.e6 18 p.

Research output: Contribution to journalArticle

139 Citations (Scopus)

Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration

Irvine, K. M., Skoien, R., Bokil, N. J., Melino, M., Thomas, G. P., Loo, D., Gabrielli, B., Hill, M. M., Sweet, M. J., Clouston, A. D. & Powell, E. E., 2014, In : World Journal of Gastroenterology. 20, 47, p. 17851–17862 13 p.

Research output: Contribution to journalArticle

Open Access
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17 Citations (Scopus)
4 Downloads (Pure)

The IFITM5 mutation c.-14C> T results in an elongated transcript expressed in human bone; and causes varying phenotypic severity of osteogenesis imperfecta type V

Lazarus, S., McInerney-Leo, A. M., McKenzie, F. A., Baynam, G., Broley, S., Cavan, B. V., Munns, C. F., Pruijs, J. E. H., Sillence, D., Terhal, P. A., Price, K., Brown, M. A., Zankl, A., Thomas, G. & Duncan, E. L., 2014, In : BMC Musculoskeletal Disorders. 15, 107, p. 1-6 6 p., 107.

Research output: Contribution to journalArticle

Open Access
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13 Citations (Scopus)
1 Downloads (Pure)
2013

Brief Report: High-Throughput Sequencing of IL23R Reveals a Low-Frequency, Nonsynonymous Single-Nucleotide Polymorphism That Is Associated With Ankylosing Spondylitis in a Han Chinese Population

Davidson, S. I., Jiang, L., Cortes, A., Wu, X., Glazov, E. A., Zheng, Y., Danoy, P. A., Liu, Y., Thomas, G. P., Brown, M. A. & Xu, H., 2013, In : Arthritis and Rheumatology. 65, 7, p. 1747-1752 6 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Expression profiling in spondyloarthropathy synovial biopsies highlights changes in expression of inflammatory genes in conjunction with tissue remodelling genes

Thomas, G. P., Duan, R., Pettit, A. R., Weedon, H., Kaur, S., Smith, M. & Brown, M. A., 2013, In : BMC Musculoskeletal Disorders. 14, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Investigating the clinical effect of resveratrol in non-alcoholic fatty liver disease: A randomised, double blind, placebo-controlled trial

Chachay, VS., Martin, J. H., Prins, JB., Whitehead, JP., O'Moore-Sullivan, T. M., Lee, P., Franklin, M., Klein, K., Taylor, PJ., Ferguson, M., Coombes, JS., Thomas, G., Cowin, G. J., Kirkpatrick, C., MacDonald, G. & Hickman, I., 2013, In : Journal of Gastroenterology and Hepatology (Australia). 28, Supplement 2, p. 78-79 2 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Sclerostin regulates release of bone mineral by osteocytes by induction of carbonic anhydrase 2

Kogawa, M., Wijenayaka, A. R., Ormsby, R. T., Thomas, G. P., Anderson, P. H., Bonewald, L. F., Findlay, D. M. & Atkins, G. J., 2013, In : Journal of Bone and Mineral Research. 28, 12, p. 2436-2448 13 p.

Research output: Contribution to journalArticle

86 Citations (Scopus)

Smg1 haploinsufficiency predisposes to tumor formation and inflammation

Roberts, T. L., Ho, U., Luff, J., Lee, C. S., Apte, S. H., MacDonald, K. PA., Raggat, L. J., Pettit, A. R., Morrow, C. A., Waters, M. J., Chen, P., Woods, R. G., Thomas, G., St. Pierre, L., Farah, C. S., Clarke, R. A., Brown, J. A. L. & Lavin, M. F., Jan 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 4, p. E285-E294 10 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Transgenic muscle-specific Nor-1 expression regulates multiple pathways that effect adiposity, metabolism, and endurance

Pearen, M. A., Goode, J. M., Fitzsimmons, R. L., Eriksson, N. A., Thomas, G. P., Cowin, G. J., Wang, S-C. M., Tuong, Z. K. & Muscat, G. EO., 2013, In : Molecular Endocrinology. 27, 11, p. 1897-1917 21 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
2012

A Mouse Model of Early-Onset Renal Failure Due to a Xanthine Dehydrogenase Nonsense Mutation

Piret, S. E., Esapa, C. T., Gorvin, C. M., Head, R. A., Loh, N. Y., Devuyst, O., Thomas, G., Brown, S. D. M., Brown, M., Croucher, P. I., Cox, R. D. & Thakker, R. V., Sep 2012, In : PLoS One. 7, 9, p. 1-10 10 p., e45217.

Research output: Contribution to journalArticle

Open Access
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5 Citations (Scopus)
12 Downloads (Pure)

A mouse with an N-Ethyl-N-nitrosourea (ENU) Induced Trp589Arg Galnt3 mutation represents a model for hyperphosphataemic familial tumoural calcinosis

Esapa, C. T., Head, R. A., Jeyabalan, J., Evans, H., Hough, T. A., Cheeseman, M. T., McNally, E. G., Carr, A. J., Thomas, G. P., Brown, M. A., Croucher, P. I., Brown, S. D., Cox, R. D. & Thakker, R. V., 2012, In : PLoS One. 7, 8, p. 1-15 15 p., e43205.

Research output: Contribution to journalArticle

Open Access
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12 Citations (Scopus)
7 Downloads (Pure)

Beta-glucan triggers spondylarthritis and Crohn's disease-like ileitis in SKG mice

Ruutu, M., Thomas, G., Steck, R., Degli-Esposti, M. A., Zinkernagel, M. S., Alexander, K., Velasco, J., Strutton, G., Tran, A., Benham, H., Rehaume, L. M., Wilson, R. J., Kikly, K., Davies, J., Pettit, A. R., Brown, M. A., McGuckin, M. A. & Thomas, R., 2012, In : Arthritis and Rheumatology. 64, 7, p. 2211-2222 12 p.

Research output: Contribution to journalArticle

126 Citations (Scopus)

Caveolin-1 deficiency leads to increased susceptibility to cell death and fibrosis in white adipose tissue: characterization of a lipodystrophic model

Martin, S., Fernandez-Rojo, M. A., Stanley, A. C., Bastiani, M., Okano, S., Nixon, S. J., Thomas, G., Stow, J. L. & Parton, R. G., 2012, In : PLoS One. 7, 9, p. 1-9 9 p., e46242.

Research output: Contribution to journalArticle

Open Access
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27 Citations (Scopus)
8 Downloads (Pure)

Discovery of candidate serum proteomic and metabolomic biomarkers in ankylosing spondylitis

Fischer, R., Trudgian, D. C., Wright, C., Thomas, G., Bradbury, L. A., Brown, M. A., Bowness, P. & Kessler, B. M., 2012, In : Molecular and Cellular Proteomics. 11, 2, p. 1-11 11 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)

Enrichment of circulating interleukin-17-secreting interleukin-23 receptor-positive γ/δ T cells in patients with active ankylosing spondylitis

Kenna, T. J., Davidson, S. I., Duan, R., Bradbury, L. A., McFarlane, J., Smith, M., Weedon, H., Street, S., Thomas, R., Thomas, G. P. & Brown, M. A., 2012, In : Arthritis and Rheumatism. 64, 5, p. 1420-1429 10 p.

Research output: Contribution to journalArticle

149 Citations (Scopus)

Excessive bone formation in a mouse model of ankylosing spondylitis is associated with decreases in Wnt pathway inhibitors

Haynes, K. R., Pettit, A. R., Duan, R., Tseng, H-W., Glant, T. T., Brown, M. A. & Thomas, G. P., 2012, In : Arthritis Research & Therapy. 14, 6, p. 1-12 12 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)

Macrophage secretory products induce an inflammatory phenotype in hepatocytes

Melino, M., Gadd, V. L., Walker, G. V., Skoien, R., Barrie, H. D., Jothimani, D., Horsfall, L., Jones, A., Sweet, M. J., Thomas, G. P., Clouston, A. D., Jonsson, J. R. & Powell, E. E., 2012, In : World Journal of Gastroenterology: WJG. 18, 15, p. 1732-1744 13 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Peripheral blood monocyte gene expression profile clinically stratifies patients with recent-onset type 1 diabetes

Irvine, K. M., Gallego, P., An, X., Best, S. E., Thomas, G., Wells, C., Harris, M., Cotterill, A. & Thomas, R., 2012, In : Diabetes. 61, 5, p. 1281-1290 10 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Ski Overexpression in Skeletal Muscle Modulates Genetic Programs That Control Susceptibility to Diet-Induced Obesity and Insulin Signaling

Diaz, M., Martel, N., Fitzsimmons, R. L., Eriksson, N. A., Cowin, G. J., Thomas, G. P., Le Cao, K-A., Muscat, G. EO. & Leong, G. M., 2012, In : Obesity. 20, 11, p. 2157-2167 11 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2011

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

The Australo-Anglo-American Spondyloarthritis Consortium, Wellcome Trust Case Control Consortium 2 & Thomas, G., 2011, In : Nature Genetics. 43, 8, p. 761-769 9 p.

Research output: Contribution to journalArticle

514 Citations (Scopus)

The Application Of Next-generation Sequencing To Identify Novel Ankylosing Spondylitis-associated Il23r Variants In A Han Chinese Population

Davidson, S., Jiang, L., Glazov, E., Cortes, A., Donskoi, M., Danoy, P., Thomas, G., Xu, H. & Brown, M., 2011, In : Internal Medicine Journal. 41, Supplement 1, p. 22 1 p.

Research output: Contribution to journalArticle

The genomics and genetics of ankylosing spondylitis

Kenna, T., Davidson, S. & Thomas, G. P., 2011, In : Advances in Genomics and Genetics. 1, p. 9-25 17 p.

Research output: Contribution to journalArticle

Whole blood transcriptional profiling in ankylosing spondylitis identifies novel candidate genes that might contribute to the inflammatory and tissue-destructive disease aspects

Pimentel-Santos, F. M., Ligeiro, D., Matos, M., Mourão, A. F., Costa, J., Santos, H., Barcelos, A., Godinho, F., Pinto, P., Cruz, M., Fonseca, J. E., Guedes-Pinto, H., Branco, J. C., Brown, M. A. & Thomas, G., 2011, In : Arthritis Research & Therapy. 13, 2, p. 1-8 8 p., R57.

Research output: Contribution to journalArticle

Open Access
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36 Citations (Scopus)
5 Downloads (Pure)

Whole-exome re-sequencing in a family quartet identifies POP1 mutations as the cause of a novel skeletal dysplasia

Glazov, E. A., Zankl, A., Donskoi, M., Kenna, T. J., Thomas, G. P., Clark, G. R., Duncan, E. L. & Brown, M. A., 2011, In : PLoS Genetics. 7, 3, p. 1-7 7 p., e1002027.

Research output: Contribution to journalArticle

Open Access
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58 Citations (Scopus)
5 Downloads (Pure)
2010

Association of STAT3 and TNFRSF1A with ankylosing spondylitis in Han Chinese

Davidson, S. I., Liu, Y., Danoy, P. A., Wu, X., Thomas, G. P., Jiang, L., Sun, L., Wang, N., Han, J. & Han, H., 2010, In : Annals of the Rheumatic Diseases. p. annrheumdis133322

Research output: Contribution to journalArticle

Cisplatin treatment induces a transient increase in tumorigenic potential associated with high interleukin-6 expression in head and neck squamous cell carcinoma

Poth, K. J., Guminski, A. D., Thomas, G. P., Leo, P. J., Jabbar, I. A. & Saunders, N. A., 2010, In : Molecular Cancer Therapeutics. 9, 8, p. 2430-2439 10 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Gene expression profiling reveals a downregulation in immune-associated genes in patients with AS

Duan, R., Leo, P., Bradbury, L., Brown, M. A. & Thomas, G., 2010, In : Annals of the Rheumatic Diseases. p. annrheumdis111690

Research output: Contribution to journalArticle

32 Citations (Scopus)

Genetics and genomics of ankylosing spondylitis

Thomas, G. P. & Brown, M. A., 2010, In : Immunological Reviews. 233, 1, p. 162-180 19 p.

Research output: Contribution to journalArticle

120 Citations (Scopus)

Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci

Consortium, A-A-A. S. & Thomas, G., 2010, In : Nature Genetics. 42, 2, p. 123-127 5 p.

Research output: Contribution to journalArticle

431 Citations (Scopus)

Genomics of ankylosing spondylitis

Thomas, G. P. & Brown, M. A., 2010, In : Discovery medicine. 10, 52, p. 263-271 9 p.

Research output: Contribution to journalArticle

Tumor-initiating activity and tumor morphology of HNSCC is modulated by interactions between clonal variants within the tumor

Cameron, S. R., Dahler, A. L., Endo-Munoz, L. B., Jabbar, I., Thomas, G. P., Leo, P. J., Poth, K., Rickwood, D., Guminski, A. & Saunders, N. A., 2010, In : Laboratory Investigation. 90, 11, p. 1594 1 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)