• 2272 Citations
  • 25 h-Index
1994 …2020

Research output per year

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Personal profile

Personal profile

Dr Cahill studied Science at the University of New South Wales, graduating with BSc (Hons 1) in Zoology with a strong Biochemistry emphasis in 1987 and a PhD from the Department of Pathology, School of Medicine of the University of NSW, working on the transcriptional regulation of the c-fos gene as an external student based at the Medizinische Hochschule in Hannover, Germany. After finishing his doctoral thesis in late 1994 he remained in the same lab for another twelve months as a “post doctoral scientist” (postdoc) before moving back to Australia in late 1995.

Being interested in signal transduction events in the cytoplasm, he was captivated in 1996 by the then emerging field of proteomics; so much so that he moved from Canberra back to Germany where from 04/1997 to 01/2000 he established a proteomics laboratory as postdoc/group leader at the University of Tuebingen. That activity later developed into the present Tuebingen Proteomics Centre. However before that centre was officially opened he had left the academic world to co-found a proteomics-based biotechnology company called ProteoSys AG, based in Mainz. There he remained as Chief Research Officer until 2007, after which he ‘moved back home’ to re-enter academic life in Australia. Dr Cahill commenced as a biochemistry lecturer at CSU in Wagga Wagga in 2008. Since then he has served at different times as School Honours Coordinator and Chair of the School Research Committee, and is currently an elected staff representative serving on both Academic Senate and the CSU Research Committee. He teaches in the areas of nutritional metabolism, biochemistry, molecular cell biology, and genomics, proteomics and bioinformatics.

Dr. Cahill's research interests cover the healthy and pathological biology of the cell signalling system surrounding the protein "Progesterone Receptor Membrane Component 1". He has recently shown that PGRMC1 phosphorylation is involved in mitochondrial morphology and metabolic function, and in epigenetic gene regulation that drives cell phenotypical plasticity. PGRMC1's phosphorylated tyrosines appeared in evolution at the same time as the gastrulation organiser and derived specialised cell types, such as neurons. We are begining to understand the broad range of effects of PGRMC1 in diseases like cancer (Warburg effect metabolism) and neurodegeneration. For instance, it is emerging that Alzheimer's disease may be caused by perturbations in PGRMC1 function, which cause all of the downstream effects commonly researched (amyloid beta, Tau. ApoE, epigentics, glucose metabolism, and mitochondrial dysfunction). The future will attest whether these unorthodox statements bear the test of time (no other Australian Alzheimer's researcher would argue this). Dr. Cahill is confident that it will be so.


Education/Academic qualification

Pathology/Molecular Cell Biology, Ph.D., The University of New South Wales

Feb 1991Aug 1994

Award Date: 06 Feb 1996

Zoology and Biochemistry, B.Sc.(Hons 1), The University of New South Wales


Award Date: 09 May 1988

External positions

Scientific Advisor (http://cogrx.com/team/), Cognition Therapeutics Inc., Pittsburgh

Aug 2013 → …

Chief Research Officer and Scientific Co-founder, ProteoSys AG, Mainz

Feb 2002Sep 2007

Postdoctoral Research Group Leader, Proteomics, Interfaculty Institute for Cell Biology, University of Tuebingen

Apr 1997Jan 2000

Postdoctoral Researcher, John Curtin School of Medical Research, Australian National University

Jan 1996Feb 1997

Postdoctoral Researcher, Hannover Medical School

Aug 1994Nov 1995

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Research Output

Early eukaryotic origins and metazoan elaboration of MAPR family proteins

Hehenberger, E., Eitel, M., Fortunato, S. A. V., Miller, D. J., Keeling, P. J. & Cahill, M. A., 08 Apr 2020, In : Molecular Phylogenetics and Evolution. 148, 106814.

Research output: Contribution to journalArticle

  • 1 Citation (Scopus)

    PGRMC1 effects on metabolism, genomic mutation and CpG methylation imply crucial roles in animal biology and disease

    Thejer, B. M., Adhikary, P. P., Teakel, S. L., Fang, J., Weston, P. A., Gurusinghe, S., Anwer, A. G., Gosnell, M., Jazayeri, J. A., Ludescher, M., Gray, L-A., Pawlak, M., Wallace, R. H., Pant, S. D., Wong, M., Fischer, T., New, E. J., Fehm, T. N., Neubauer, H., Goldys, E. M. & 3 others, Quinn, J. C., Weston, L. A. & Cahill, M. A., 15 Apr 2020, In : BMC Molecular and Cell Biology. 21, p. 26

    Research output: Contribution to journalArticle

  • 1 Citation (Scopus)

    PGRMC1 phosphorylation affects cell shape, motility, glycolysis, mitochondrial form and function, and tumor growth

    Thejer, B., Adhikary, P., Kaur, A., Teakel, S., Van Oosterum, A., Seth, I., Pajic, M., Hannan, K. M., Pavy, M., Poh, P., Jazayeri, J., Zaw, T., Pascovici, D., Ludescher, M., Pawlak, M., Cassano, J. C., Turnbull, L., Jazayeri, M., James, A. C., Coorey, C. P. & 11 others, Roberts, T. L., Kinder, S. J., Hannan, R. D., Patrick, E., Molloy, M. P., New, E. J., Fehm, T., Neubauer, H., Goldys, E. M., Weston, L. & Cahill, M. A., 03 Apr 2020, In : BMC Molecular and Cell Biology. 21, p. 1-24 24 p., 24.

    Research output: Contribution to journalArticle

  • 4 Citations (Scopus)

    Proceedings from the fourth international symposium on sigma-2 receptors: Role in health and disease

    Izzo, N. J., Colom-Cadena, M., Riad, A. A., Xu, J., Singh, M., Abate, C., Cahill, M. A., Spires-Jones, T. L., Bowen, W. D., Mach, R. H. & Catalano, S. M., 12 Sep 2020, (Accepted/In press) In : eNeuro.

    Research output: Contribution to journalArticle


    Cells (Journal)

    Mike Cahill (Reviewer)

    19 May 2020

    Activity: Publication peer-review and editorial workPeer review responsibility, including review panel or committee

    Livestreaming BMS241 Molecular Cell Biology: On campus lectures are streamed online with interactive quizzes so distance students participate via Adobe Connect

    Mike Cahill (Presenter)

    18 Feb 202019 Feb 2020

    Activity: Academic engagement & professional developmentOnline content/delivery

    Fertility and Sterility (Journal)

    Mike Cahill (Reviewer)

    04 Jan 2020

    Activity: Publication peer-review and editorial workPeer review responsibility, including review panel or committee

    Archives of Biochemistry and Biophysics (Journal)

    Mike Cahill (Reviewer)

    08 Apr 2019

    Activity: Publication peer-review and editorial workPeer review responsibility, including review panel or committee

    Fertility and Sterility (Journal)

    Mike Cahill (Reviewer)

    24 Sep 2019

    Activity: Publication peer-review and editorial workPeer review responsibility, including review panel or committee