Research output per year
Research output per year
- 1 - 50 out of 212 results
Search results
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2024
Efficacies and ADME properties of redox active methylene blue and phenoxazine analogues for use in new antimalarial triple drug combinations with amino-artemisinins
Watson, D. J., Laing, L., Petzer, J. P., Wong, H. N., Parkinson, C. J., Wiesner, L. & Haynes, R. K., Jan 2024, In: Frontiers in Pharmacology. 14, p. 1-14 14 p., 1308400.Research output: Contribution to journal › Article › peer-review
Open AccessFile36 Downloads (Pure) -
2023
Artemisia species and their active constituents for treating Schistosomiasis
Taljaard, L., Haynes, R. K. & van der Kooy, F., Oct 2023, In: Revista Brasileira de Farmacognosia. 33, 5, p. 875-885 11 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile1 Citation (Scopus)75 Downloads (Pure) -
Assessment of thermal and hydrolytic stabilities and aqueous solubility of artesunate for formulation studies
Bezuidenhout, J. W., Aucamp, M., Stieger, N., Liebenberg, W. & Haynes, R. K., Jan 2023, In: AAPS PharmSciTech. 24, 1, 7 p., 33.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
Combining computational and experimental evidence on the activity of antimalarial drugs on papain-like protease of SARS-CoV-2: A repurposing study
Ribaudo, G., Yun, X., Ongaro, A., Oselladore, E., Ng, J. L., Haynes, R. K., Law, B. Y. K., Memo, M., Wong, V. K. W., Coghi, P. & Gianoncelli, A., Apr 2023, In: Chemical Biology and Drug Design. 101, 4, p. 809-818 10 p.Research output: Contribution to journal › Article › peer-review
3 Citations (Scopus) -
Development of a HPLC method for analysis of a combination of clofazimine, isoniazid, pyrazinamide, and rifampicin incorporated into a dermal self-double-emulsifying drug delivery system
Staden, D. V., Haynes, R. K., Van der Kooy, F. & Viljoen, J. M., Dec 2023, In: Methods and Protocols. 6, 6, 7 p., 104.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)40 Downloads (Pure) -
Discovery of artemisinin in Artemisia annua, its current production, and relevance to sub-Saharan Africa
Lee, B. J., Weyers, M., Haynes, R. K. & van der Kooy, F., Feb 2023, In: South African Journal of Botany. 153, p. 21-27 7 p.Research output: Contribution to journal › Review article › peer-review
11 Citations (Scopus) -
In Vitro versus in mice: Efficacy and safety of decoquinate and Quinoline-O-Carbamate derivatives against experimental infection with Neospora caninum tachyzoites
Ramseier, J., Imhof, D., Hänggeli, K. P. A., Anghel, N., Boubaker, G., Beteck, R. M., Ortega-Mora, L. M., Haynes, R. K. & Hemphill, A., Mar 2023, In: Pathogens. 12, 3, p. 1-15 15 p., 447.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)47 Downloads (Pure) -
Proteomic characterization of Toxoplasma gondii ME49 derived strains resistant to the artemisinin derivatives artemiside and artemisone implies potential mode of action independent of ROS formation
Müller, J., Schlange, C., Heller, M., Uldry, A. C., Braga-Lagache, S., Haynes, R. K. & Hemphill, A., Apr 2023, In: International Journal for Parasitology: Drugs and Drug Resistance. 21, p. 1-12 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)46 Downloads (Pure) -
Single and combination treatment of Toxoplasma gondii infections with a bumped kinase inhibitor and artemisone in vitro and with artemiside in experimentally infected mice
Schlange, C., Muller, J., Imhof, D., Hänggeli, K. P. A., Boubaker, G., Ortega-Mora, L. M., Wong, H. N., Haynes, R. K., Van Voorhis, W. C. & Hemphill, A., Dec 2023, In: Experimental Parasitology. 255, p. 1-13 13 p., 108655.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)41 Downloads (Pure) -
The development of dermal self-double-emulsifying drug delivery systems: Preformulation studies as the keys to success
van Staden, D., Haynes, R. K. & Viljoen, J. M., Oct 2023, In: Pharmaceuticals. 16, 10, p. 1-21 21 p., 1348.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Downloads (Pure) -
The science of selecting excipients for dermal self-emulsifying drug delivery systems
van Staden, D., Haynes, R. K. & Viljoen, J. M., Apr 2023, In: Pharmaceutics. 15, 4, p. 1-19 19 p., 1293.Research output: Contribution to journal › Review article › peer-review
Open AccessFile2 Citations (Scopus)43 Downloads (Pure) -
2022
Adapting clofazimine for treatment of cutaneous tuberculosis by using self-double-emulsifying drug delivery systems
van Staden, D., Haynes, R. K. & Viljoen, J. M., 15 Jun 2022, In: Antibiotics. 11, 6, 25 p., 806.Research output: Contribution to journal › Review article › peer-review
Open AccessFile8 Citations (Scopus)96 Downloads (Pure) -
Antimalarial and antitumour activities of the steroidal quinone-methide celastrol and its combinations with artemiside, artemisone and methylene blue
Ng, J. P. L., Han, Y., Yang, L. J., Birkholtz, L.-M., Coertzen, D., Wong, H. N., Haynes, R. K., Coghi, P. & Wong, V. K. W., 2022, In: Frontiers in Pharmacology. 13, 12 p., 988748.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)46 Downloads (Pure) -
Control of 11-Aza:4-X-SalA cocrystal polymorphs using heteroseeds that switch on/off halogen bonding
Li, K., Roy, M., Nisar, M., Wong, L. W. Y., Sung, H. H. Y., Haynes, R. K. & Williams, I. D., Oct 2022, In: Crystals. 12, 10, 17 p., 1368.Research output: Contribution to journal › Article › peer-review
Open AccessFile38 Downloads (Pure) -
Dual production of solar energy and important plant-derived active pharmaceutical ingredients: Artemisinin, a pilot study
Lee, B. J., Van Niekerk, S. E., Jordaan, A., Legoabe, L. J., Haynes, R. K. & van der Kooy, F., Nov 2022, In: South African Journal of Botany. 150, p. 473-477 5 p.Research output: Contribution to journal › Article › peer-review
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In vitro activity of the arylaminoartemisinin GC012 against Helicobacter pylori and its effects on biofilm
Sisto, F., Carradori, S., D’alessandro, S., Santo, N., Lattuada, N., Haynes, R. K., Taramelli, D. & Grande, R., Jul 2022, In: Pathogens. 11, 7, p. 1-17 17 p., 740.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)47 Downloads (Pure) -
In vitro antischistosomal activity of Artemisia annua and Artemisia afra extracts
Taljaard, L., Probst, A., Tornow, R., Keiser, J., Haynes, R. K. & van der Kooy, F., Aug 2022, In: Phytomedicine Plus. 2, 3, p. 1-6 6 p., 100279.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)32 Downloads (Pure) -
The evaluation of ADME and pharmacokinetic properties of decoquinate derivatives for the treatment of malaria
Watson, D. J., Laing, L., Beteck, R. M., Gibhard, L., Haynes, R. K. & Wiesner, L., 19 Aug 2022, In: Frontiers in Pharmacology. 13, 11 p., 957690.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)48 Downloads (Pure) -
2021
A drug repurposing approach for antimalarials interfering with SARS-COV-2 spike protein receptor binding domain (RBD) and human angiotensin-converting enzyme 2 (ACE2)
Coghi, P., Yang, L. J., Ng, J. P. L., Haynes, R. K., Memo, M., Gianoncelli, A., Wong, V. K. W. & Ribaudo, G., Oct 2021, In: Pharmaceuticals. 14, 10, 13 p., 954.Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Citations (Scopus)39 Downloads (Pure) -
Assessment of the activity of decoquinate and its quinoline‐ o‐carbamate derivatives against toxoplasma gondii in vitro and in pregnant mice infected with t. Gondii oocysts
Ramseier, J., Imhof, D., Anghel, N., Hänggeli, K., Beteck, R. M., Balmer, V., Ortega‐mora, L. M., Sanchez‐sanchez, R., Ferre, I., Haynes, R. K. & Hemphill, A., 01 Nov 2021, In: Molecules. 26, 21, 18 p., 6393.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)41 Downloads (Pure) -
The artemiside-artemisox-artemisone-m1 tetrad: Efficacies against blood stage P. falciparum parasites, dmpk properties, and the case for artemiside
Gibhard, L., Coertzen, D., Reader, J., van der Watt, M. E., Birkholtz, L. M., Wong, H. N., Batty, K. T., Haynes, R. K. & Wiesner, L., Dec 2021, In: Pharmaceutics. 13, 12, p. 1-18 18 p., 2066.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)47 Downloads (Pure) -
Toward new transmission-blocking combination therapies: Pharmacokinetics of 10-amino-artemisinins and 11-aza-artemisinin and comparison with dihydroartemisinin and artemether
Watson, D. J., Laing, L., Gibhard, L., Wong, H. N., Haynes, R. K. & Wiesner, L., Aug 2021, In: Antimicrobial Agents and Chemotherapy. 65, 8, p. 1-16 16 p., e00990.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Citations (Scopus)69 Downloads (Pure) -
Varying degrees of homostructurality in a series of cocrystals of antimalarial drug 11-azaartemisinin with salicylic acids
Roy, M., Li, K., Nisar, M., Wong, L. W. Y., Sung, H. H. Y., Haynes, R. K. & Williams, I. D., 01 Jun 2021, In: Acta Crystallographica Section C: Structural Chemistry. 77, p. 262-270 9 p.Research output: Contribution to journal › Article › peer-review
4 Citations (Scopus) -
2020
Accumulation of TB-Active compounds in murine organs relevant to infection by mycobacterium tuberculosis
Tanner, L., Haynes, R. K. & Wiesner, L., 19 May 2020, In: Frontiers in Pharmacology. 11, 8 p., 724.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)39 Downloads (Pure) -
Antimalarial N1, N3-Dialkyldioxonaphthoimidazoliums: Synthesis, biological activity, and structure-activity relationships
Ahenkorah, S., Coertzen, D., Tong, J. X., Fridianto, K., Wittlin, S., Birkholtz, L. M., Tan, K. S. W., Lam, Y., Go, M. L. & Haynes, R. K., 09 Jan 2020, In: ACS Medicinal Chemistry Letters. 11, 1, p. 49-55 7 p.Research output: Contribution to journal › Letter › peer-review
13 Citations (Scopus) -
Anti-melanoma activities of artemisone and prenylated amino-artemisinins in combination with known anticancer drugs
Wong, H. N., Lewies, A., Haigh, M., Viljoen, J. M., Wentzel, J. F., Haynes, R. K. & du Plessis, L. H., 29 Sept 2020, In: Frontiers in Pharmacology. 11, 14 p., 558894.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (Scopus)51 Downloads (Pure) -
Optimal 10-aminoartemisinins with potent transmission-blocking capabilities for new artemisinin combination therapies–activities against blood stage P. falciparum including PfKI3 C580Y mutants and liver stage P. berghei parasites
Wong, H. N., Padín-Irizarry, V., van der Watt, M. E., Reader, J., Liebenberg, W., Wiesner, L., Smith, P., Eribez, K., Winzeler, E. A., Kyle, D. E., Birkholtz, L. M., Coertzen, D. & Haynes, R. K., 10 Jan 2020, In: Frontiers in Chemistry. 7, 16 p., 901.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus)50 Downloads (Pure) -
2019
An in vitro ADME and in vivo pharmacokinetic study of novel TB-Active decoquinate derivatives
Tanner, L., Haynes, R. K. & Wiesner, L., 18 Feb 2019, In: Frontiers in Pharmacology. 10, 10 p., 120.Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Citations (Scopus)43 Downloads (Pure) -
Anti-mycobacterial peroxides: A new class of agents for development against tuberculosis
van der Westhuyzen, C. W., Haynes, R. K., Panayides, J. L., Wiid, I. & Parkinson, C. J., 2019, In: Medicinal Chemistry. 16, 3, p. 392-402 11 p.Research output: Contribution to journal › Article › peer-review
4 Citations (Scopus) -
Artemisone demonstrates synergistic antiviral activity in combination with approved and experimental drugs active against human cytomegalovirus
Oiknine-Djian, E., Bar-On, S., Laskov, I., Lantsberg, D., Haynes, R. K., Panet, A. & Wolf, D. G., Dec 2019, In: Antiviral Research. 172, 4 p., 104639.Research output: Contribution to journal › Article › peer-review
24 Citations (Scopus) -
Development of pyridyl thiosemicarbazones as highly potent agents for the treatment of malaria after oral administration
Parkinson, C. J., Birrell, G. W., Chavchich, M., MacKenzie, D., Haynes, R. K., De Kock, C., Richardson, D. R. & Edstein, M. D., Oct 2019, In: The Journal of antimicrobial chemotherapy. 74, 10, p. 2965-2973 9 p.Research output: Contribution to journal › Article › peer-review
8 Citations (Scopus)31 Downloads (Pure) -
In Vitro efficacies, ADME, and Pharmacokinetic properties of Phenoxazine Derivatives active against Mycobacterium tuberculosis
Tanner, L., Evans, J. C., Seldon, R., Jordaan, A., Warner, D. F., Haynes, R. K., Parkinson, C. J. & Wiesner, L., 01 Nov 2019, In: Antimicrobial Agents and Chemotherapy. 63, 11, p. 1-10 10 p., e01010-19.Research output: Contribution to journal › Article › peer-review
5 Citations (Scopus) -
The evaluation of metal co-ordinating Bis-Thiosemicarbazones as potential anti-malarial Agents
Akladios, F. N., Andrew, S. D., Boog, S. J., de Kock, C., Haynes, R. K. & Parkinson, C. J., 01 Jan 2019, In: Medicinal chemistry (Shariqah (United Arab Emirates)). 15, 1, p. 51-58 8 p.Research output: Contribution to journal › Article › peer-review
9 Citations (Scopus) -
The evaluation of the anti-cancer drug elesclomol that forms a redox-active copper chelate as a potential anti-tubercular drug
Ngwane, A. H., Petersen, R. D., Baker, B., Wiid, I., Wong, H. N. & Haynes, R. K., May 2019, In: IUBMB Life. 71, 5, p. 532-538 7 p.Research output: Contribution to journal › Article › peer-review
19 Citations (Scopus) -
Topical delivery of artemisone, clofazimine and decoquinate encapsulated in vesicles and their in vitro efficacy against mycobacterium tuberculosis
van Zyl, L., Viljoen, J. M., Haynes, R. K., Aucamp, M., Ngwane, A. H. & du Plessis, J., 01 Jan 2019, In: AAPS PharmSciTech. 20, 1, 11 p., 33.Research output: Contribution to journal › Article › peer-review
23 Citations (Scopus) -
2018
11-Azaartemisinin cocrystals with preserved lactam: Acid heterosynthons
Nisar, M., Sung, H. H. Y., Puschmann, H., Lakerveld, R., Haynes, R. K. & Williams, I. D., Mar 2018, In: CrystEngComm. 20, 9, p. 1205-1219 15 p.Research output: Contribution to journal › Article › peer-review
14 Citations (Scopus) -
Absorptive and secretory transport of selected artemisinin derivatives across Caco-2 cell monolayers
Heyns, J., Willers, C., Haynes, R. K., Wong, H. N., Hamman, J. & Gouws, C., 2018, In: Current Drug Delivery. 15, 8, p. 1183-1192 10 p.Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus) -
Accessible and distinct decoquinate derivatives active against Mycobacterium tuberculosis and apicomplexan parasites
Beteck, R. M., Seldon, R., Coertzen, D., van der Watt, M. E., Reader, J., Mackenzie, J. S., Lamprecht, D. A., Abraham, M., Eribez, K., Müller, J., Rui, F., Zhu, G., de Grano, R. V., Williams, I. D., Smit, F. J., Steyn, A. J. C., Winzeler, E. A., Hemphill, A., Birkholtz, L. M. & Warner, D. F. & 2 others, , 01 Dec 2018, In: Communications Chemistry. 1, 1, p. 1-11 11 p., 62.Research output: Contribution to journal › Article › peer-review
Open AccessFile26 Citations (Scopus)75 Downloads (Pure) -
Artemisone and artemiside are potent panreactive antimalarial agents that also synergize redox imbalance in plasmodium falciparum transmissible gametocyte stages
Coertzen, D., Reader, J., Van Der Watt, M., Nondaba, S. H., Gibhard, L., Wiesner, L., Smith, P., D’Alessandro, S., Taramelli, D., Wong, H. N., Du Preez, J. L., Wu, R. W. K., Birkholtz, L. M. & Haynes, R. K., Aug 2018, In: Antimicrobial Agents and Chemotherapy. 62, 8, p. 1-17 17 p., e02214-17.Research output: Contribution to journal › Article › peer-review
Open AccessFile30 Citations (Scopus)48 Downloads (Pure) -
Cocrystals of the antimalarial drug 11-azaartemisinin with three alkenoic acids of 1:1 or 2:1 stoichiometry
Nisar, M., Wong, L. W. Y., Sung, H. H. Y., Haynes, R. K. & Williams, I. D., 2018, In: Acta Crystallographica Section C: Structural Chemistry. 74, p. 742-751 10 p.Research output: Contribution to journal › Article › peer-review
12 Citations (Scopus) -
Corrigendum to ‘In vitro activity of artemisone and artemisinin derivatives against extracellular and intracellular Helicobacter pylori’ (International Journal of Antimicrobial Agents (2016) 48(1) (101–105)(S0924857916300747)(10.1016/j.ijantimicag.2016.03.018))
Sisto, F., Scaltrito, M. M., Masia, C., Bonomi, A., Coccè, V., Marano, G., Haynes, R. K., Miani, A., Farronato, G. & Taramelli, D., Oct 2018, In: International Journal of Antimicrobial Agents. 52, 4, p. 528-528 1 p.Research output: Contribution to journal › Comment/debate › peer-review
1 Citation (Scopus) -
Evaluation and optimization of synthetic routes from dihydroartemisinin to the alkylamino-artemisinins artemiside and artemisone: A test of N-glycosylation methodologies on a lipophilic peroxide
Chan, W. C., Wai Chan, D. H., Lee, K. W., Tin, W. S., Wong, H. N. & Haynes, R. K., 20 Sept 2018, In: Tetrahedron. 74, 38, p. 5156-5171 16 p.Research output: Contribution to journal › Article › peer-review
15 Citations (Scopus) -
Facile preparation of N-glycosylated 10-piperazinyl artemisinin derivatives and evaluation of their antimalarial and cytotoxic activities
Wu, Y., Parapini, S., Williams, I. D., Misiano, P., Wong, H. N., Taramelli, D., Basilico, N. & Haynes, R. K., Jul 2018, In: Molecules. 23, 7, p. 1-19 19 p., 1713.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Citations (Scopus)40 Downloads (Pure) -
Formulation of natural oil nano-emulsions for the topical delivery of clofazimine, artemisone and decoquinate
Burger, C., Aucamp, M., du Preez, J., Haynes, R. K., Ngwane, A., du Plessis, J. & Gerber, M., 01 Oct 2018, In: Pharmaceutical Research. 35, 10, 186.Research output: Contribution to journal › Article › peer-review
17 Citations (Scopus) -
Preliminary evaluation of artemisinin–cholesterol conjugates as potential drugs for the treatment of intractable forms of malaria and tuberculosis
Morake, M., Coertzen, D., Ngwane, A., Wentzel, J. F., Wong, H. N., Smit, F. J., Birkholtz, L. M., Pietersen, R. D., Baker, B., Wiid, I., N'Da, D. D. & Haynes, R. K., 08 Jan 2018, In: ChemMedChem. 13, 1, p. 67-77 11 p.Research output: Contribution to journal › Article › peer-review
15 Citations (Scopus) -
Synthesis, antimalarial activities and cytotoxicities of amino-artemisinin-1,2-disubstituted ferrocene hybrids
de Lange, C., Coertzen, D., Smit, F. J., Wentzel, J. F., Wong, H. N., Birkholtz, L.-M., Haynes, R. K. & N'Da, D. D., 15 Oct 2018, In: Bioorganic and Medicinal Chemistry Letters. 28, 19, p. 3161-3163 3 p.Research output: Contribution to journal › Article › peer-review
29 Citations (Scopus) -
Synthesis, in vitro antimalarial activities and cytotoxicities of amino-artemisinin-ferrocene derivatives
de Lange, C., Coertzen, D., Smit, F. J., Wentzel, J. F., Wong, H. N., Birkholtz, L.-M., Haynes, R. K. & N'Da, D. D., 01 Feb 2018, In: Bioorganic and Medicinal Chemistry Letters. 28, 3, p. 289-292 4 p.Research output: Contribution to journal › Article › peer-review
29 Citations (Scopus) -
The artemisinin derivative artemisone is a potent inhibitor of human cytomegalovirus replication
Oiknine-Djian, E., Weisblum, Y., Panet, A., Wong, H. N., Haynes, R. K. & Wolfa, D. G., Jul 2018, In: Antimicrobial Agents and Chemotherapy. 62, 7, p. 1-13 13 p., e00288-18.Research output: Contribution to journal › Article › peer-review
Open AccessFile41 Citations (Scopus)45 Downloads (Pure) -
2017
Activities of 11-azaartemisinin and N-sulfonyl derivatives against asexual and transmissible malaria parasites
Harmse, R., Coertzen, D., Wong, H. N., Smit, F. J., van der Watt, M. E., Reader, J., Nondaba, S. H., Birkholtz, L. M., Haynes, R. K. & N'Da, D. D., 19 Dec 2017, In: ChemMedChem. 12, 24, p. 2086-2093 8 p.Research output: Contribution to journal › Article › peer-review
18 Citations (Scopus) -
Activities of 11-azaartemisinin and n-sulfonyl derivatives against Neospora caninum and comparative cytotoxicities
Harmse, R., Wong, H. N., Smit, F. J., Müller, J., Hemphill, A., N'Da, D. D. & Haynes, R. K., 19 Dec 2017, In: ChemMedChem. 12, 24, p. 2094-2098 5 p.Research output: Contribution to journal › Article › peer-review
15 Citations (Scopus)