This research project will advance evidence-based policy and practical actions to strengthen human health against adverse climate impacts within livestock-keeping communities (LKCs) in Kyrgyzstan in Central Asia. Adopting a One Health approach, it will generate evidence that is representative of large parts of Central Asia and, in so doing, support positive policy reform such as called for within the Central Asia One Health Regional Framework for Action and other strategies. Utilising mixed methods, a transdisciplinary team and a collaborative approach with government, community and multilateral stakeholders, the research project will examine and describe the human health impacts of climate change within LKCs in Kyrgyzstan, a country where like much of Central Asia livestock farming is of key importance to culture, livelihoods, and nutritional security. Adopting a One Health approach will enable examination of the complex associations between climate change and human health while mindful of the nuanced, contextual and cultural influences operating at the intersections between human health, livestock and agriculture. We will generate evidence for the feasibility of effective action and necessary policy development that addresses human health vulnerabilities and strengthens resilience and adaptation to climate change with a particular focus on Kyrgyzstan.