α-Tocopherol does not inhibit hypochlorite-induced oxidation of apolipoprotein B-100 of low-density lipoprotein

Linda J. Hazell, Roland Stocker

Research output: Contribution to journalArticlepeer-review

67 Citations (Scopus)

Abstract

The amount of α-tocopherol (α-TOH) can dramatically alter the extent of radical-induced oxidation of low density lipoprotein (LDL) lipids, a process generally thought to be important in atherogenesis. However, LDL with atherogenic features can also be formed in vitro by exposure to the strong non-radical oxidant hypochlorite (HOCl), which preferentially oxidises LDL apolipoprotein B-100. Here we show that varying LDL content of α-TOH by vitamin supplementation or depletion has no effect on the extent of HOCl-induced oxidation of apolipoprotein B-100 as measured by the loss of lysine and tryptophan residues, and the alteration in relative electrophoretic mobility of the lipoprotein particle.
Original languageEnglish
Pages (from-to)541-544
Number of pages4
JournalFEBS Letters
Volume414
Issue number3
DOIs
Publication statusPublished - 15 Sep 1997

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