18F-fluorodeoxyglucose positron emission tomography/computed tomography in combination with clinical data in predicting overall survival in non-small-cell lung cancer patients: a retrospective study

Paulina Cegla, Geoff Currie

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Positron emission tomography/computed tomography (PET/CT) has an established role in evaluating patients with lung cancer. The aim of this work was to assess the predictive capability of [ 18F]Fluorodeoxyglucose ([ 18F]FDG) PET/CT parameters on overall survival (OS) in lung cancer patients using an artificial neural network (ANN) in parallel with conventional statistical analysis. Methods: Retrospective analysis was performed on a group of 165 lung cancer patients (98M, 67F). PET features associated with the primary tumor: maximum and mean standardized uptake value (SUV max, SUV mean), total lesion glycolysis (TLG) metabolic tumor volume (MTV) and area under the curve-cumulative SUV histogram (AUC-CSH) and metastatic lesions (SUV maxtotal, SUV meantotal, TLG total, and MTV total) were evaluated. In parallel with conventional statistical analysis (Chi-Square analysis for nominal data, Student's t test for continuous data), the data was evaluated using an ANN. There were 97 input variables in 165 patients using a binary classification of either below, or greater than/equal to median survival post primary diagnosis. Additionally, phantom study was performed to assess the most optimal contouring method. Results: Males had statistically higher SUV max (mean: 10.7 vs 8.9; p = 0.020), MTV (mean: 66.5 cm 3 vs. 21.5 cm 3; p = 0.001), TLG (mean 404.7 vs. 115.0; p = 0.003), TLG total (mean: 946.7 vs. 433.3; p = 0.014) and MTV total (mean: 242.0 cm 3 vs. 103.7 cm 3; p = 0.027) than females. The ANN after training and validation was optimised with a final architecture of 4 scaling layer inputs (TLG total, SUV maxtotal, SUV meantotal and disease stage) and receiving operator characteristic (ROC) analysis demonstrated an AUC of 0.764 (sensitivity of 92.3%, specificity of 57.1%). Conclusion: Conventional statistical analysis and the ANN provided concordant findings in relation to variables that predict decreased survival. The ANN provided a weighted algorithm of the 4 key features to predict decreased survival. Implication for practice: Identification of parameters which can predict survival in lung cancer patients might be helpful in choosing the group of patients who require closer look during the follow-up.

Original languageEnglish
Pages (from-to)971-977
Number of pages7
JournalRadiography
Volume30
Issue number3
DOIs
Publication statusPublished - May 2024

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