Abstract
Objective To determine whether [18F]FDG PET/CT and hematological parameters provide supportive data to determine HPV status in HNSCC patients.
Methods Retrospective analysis of clinical and diagnostic data from 106 patients with HNSCC: 26.4% HPV-positive and 73.6% HPV-negative was performed. The following semiquantitative PET/CT parameters for the primary tumor and hottest lymph node and liver were evaluated: SUVmax, SUVmean, TotalSUV, MTV, TLG, maximum, mean and TLG tumor-to-liver ratio (TLRmax, TLRmean,TLRTLG) and heterogeneity index (HI). Following hematological variables were assessed: white blood cell (WBC); lymphocyte (LYMPH); neutrophil (NEU),monocyte (MON); platelet (PLT); neutrophil-to-lymphocyte ratio (NRL); lymphocyte-to-monocyte ratio (LMR); platelet-to lymphocyte ratio (PLR) and monocyte-to-lymphocyte ratio (MLR). Conventional statistical analyses were performed in parallel with an artificial neural network analysis (Neural Analyzer, v. 2.9.5).
Results Significant between-group differences were observed for two of the semiquantitative PET/CT parameters, with higher values in the HPV-negative group: primary tumor MTV (22.2 vs 9.65; p=0.023), and TLRmax (3.50 vs 2.46; p=0.05). The HPV-negative group also had a significantly higher NEU count (4.84 vs. 6.04; p=0.04), NEU% (58.2 vs. 66.2; p=0.007), and NRL% (2.69 vs. 3.94; p=0.038). Based on ROC analysis (sensitivity 50%, specificity 80%, AUC 0.5), the following variables were independent predictors of HPV-negativity: primary tumor with SUVmax >10; TotalSUV >2800; MTV >23.5; TLG >180; TLRmax >3.7; TLRTLG >5.7; and oropharyngeal localization.
Conclusion Several semiquantitative parameters derived from [18F]FDG PET/CT imaging of the primary tumor (SUVmax, TotalSUV, MTV, TLG, TLRmax and TLRTLG) were independent predictors of HPV-negativity.
Methods Retrospective analysis of clinical and diagnostic data from 106 patients with HNSCC: 26.4% HPV-positive and 73.6% HPV-negative was performed. The following semiquantitative PET/CT parameters for the primary tumor and hottest lymph node and liver were evaluated: SUVmax, SUVmean, TotalSUV, MTV, TLG, maximum, mean and TLG tumor-to-liver ratio (TLRmax, TLRmean,TLRTLG) and heterogeneity index (HI). Following hematological variables were assessed: white blood cell (WBC); lymphocyte (LYMPH); neutrophil (NEU),monocyte (MON); platelet (PLT); neutrophil-to-lymphocyte ratio (NRL); lymphocyte-to-monocyte ratio (LMR); platelet-to lymphocyte ratio (PLR) and monocyte-to-lymphocyte ratio (MLR). Conventional statistical analyses were performed in parallel with an artificial neural network analysis (Neural Analyzer, v. 2.9.5).
Results Significant between-group differences were observed for two of the semiquantitative PET/CT parameters, with higher values in the HPV-negative group: primary tumor MTV (22.2 vs 9.65; p=0.023), and TLRmax (3.50 vs 2.46; p=0.05). The HPV-negative group also had a significantly higher NEU count (4.84 vs. 6.04; p=0.04), NEU% (58.2 vs. 66.2; p=0.007), and NRL% (2.69 vs. 3.94; p=0.038). Based on ROC analysis (sensitivity 50%, specificity 80%, AUC 0.5), the following variables were independent predictors of HPV-negativity: primary tumor with SUVmax >10; TotalSUV >2800; MTV >23.5; TLG >180; TLRmax >3.7; TLRTLG >5.7; and oropharyngeal localization.
Conclusion Several semiquantitative parameters derived from [18F]FDG PET/CT imaging of the primary tumor (SUVmax, TotalSUV, MTV, TLG, TLRmax and TLRTLG) were independent predictors of HPV-negativity.
| Original language | English |
|---|---|
| Pages (from-to) | 22-31 |
| Journal | Nuklearmedizin - NuclearMedicine |
| Volume | 64 |
| Issue number | 1 |
| Early online date | 2024 |
| DOIs | |
| Publication status | Published - 2025 |
