A comparison study of different physical treatments on cartilage matrix derived porous scaffolds for tissue engineering applications

Ali Moradi; Sumit Pramanik; Forough Ataollahi; Alizan Abdul Khalil; Tunku Kamarul; Belinda Pingguan-Murphy

doi:10.1088%2F1468-6996%2F15%2F6%2F065001

A comparison study of different physical treatments on cartilage matrix derived porous scaffolds for tissue engineering applications

Ali Moradi, Sumit Pramanik, Forough Ataollahi, Alizan Abdul Khalil, Tunku Kamarul, Belinda Pingguan-Murphy

University of Malaya

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

13 Downloads (Pure)

Abstract

Native cartilage matrix derived (CMD) scaffolds from various animal and human sources have drawn attention in cartilage tissue engineering due to the demonstrable presence of bioactive components. Different chemical and physical treatments have been employed to enhance the micro-architecture of CMD scaffolds. In this study we have assessed the typical effects of physical cross-linking methods, namely ultraviolet (UV) light, dehydrothermal (DHT) treatment, and combinations of them on bovine articular CMD porous scaffolds with three different matrix concentrations (5%, 15% and 30%) to assess the relative strengths of each treatment. Our findings suggest that UV and UV–DHT treatments on 15% CMD scaffolds can yield architecturally optimal scaffolds for cartilage tissue engineering.

Original language	English
Article number	065001
Pages (from-to)	1-12
Number of pages	12
Journal	Science and Technology of Advanced Materials
Volume	15
Issue number	6
DOIs	https://doi.org/10.1088%2F1468-6996%2F15%2F6%2F065001
Publication status	Published - 2014

Access to Document

10.1088%2F1468-6996%2F15%2F6%2F065001Licence: CC BY

12090196_Published articleFinal published version, 3.99 MBLicence: CC BY

Cite this

@article{1c6cb303b08d4b73ae51d2bac5367fa8,

title = "A comparison study of different physical treatments on cartilage matrix derived porous scaffolds for tissue engineering applications",

abstract = "Native cartilage matrix derived (CMD) scaffolds from various animal and human sources have drawn attention in cartilage tissue engineering due to the demonstrable presence of bioactive components. Different chemical and physical treatments have been employed to enhance the micro-architecture of CMD scaffolds. In this study we have assessed the typical effects of physical cross-linking methods, namely ultraviolet (UV) light, dehydrothermal (DHT) treatment, and combinations of them on bovine articular CMD porous scaffolds with three different matrix concentrations (5%, 15% and 30%) to assess the relative strengths of each treatment. Our findings suggest that UV and UV–DHT treatments on 15% CMD scaffolds can yield architecturally optimal scaffolds for cartilage tissue engineering.",

keywords = "Cartilage matrix, Porous scaffold, Cross-linking, Physical treatment",

author = "Ali Moradi and Sumit Pramanik and Forough Ataollahi and Khalil, {Alizan Abdul} and Tunku Kamarul and Belinda Pingguan-Murphy",

note = "Includes bibliographical references.",

year = "2014",

doi = "10.1088%2F1468-6996%2F15%2F6%2F065001",

language = "English",

volume = "15",

pages = "1--12",

journal = "Science and Technology of Advanced Materials",

issn = "1468-6996",

publisher = "IOP Publishing Ltd.",

number = "6",

}

TY - JOUR

T1 - A comparison study of different physical treatments on cartilage matrix derived porous scaffolds for tissue engineering applications

AU - Moradi, Ali

AU - Pramanik, Sumit

AU - Ataollahi, Forough

AU - Khalil, Alizan Abdul

AU - Kamarul, Tunku

AU - Pingguan-Murphy, Belinda

N1 - Includes bibliographical references.

PY - 2014

Y1 - 2014

N2 - Native cartilage matrix derived (CMD) scaffolds from various animal and human sources have drawn attention in cartilage tissue engineering due to the demonstrable presence of bioactive components. Different chemical and physical treatments have been employed to enhance the micro-architecture of CMD scaffolds. In this study we have assessed the typical effects of physical cross-linking methods, namely ultraviolet (UV) light, dehydrothermal (DHT) treatment, and combinations of them on bovine articular CMD porous scaffolds with three different matrix concentrations (5%, 15% and 30%) to assess the relative strengths of each treatment. Our findings suggest that UV and UV–DHT treatments on 15% CMD scaffolds can yield architecturally optimal scaffolds for cartilage tissue engineering.

AB - Native cartilage matrix derived (CMD) scaffolds from various animal and human sources have drawn attention in cartilage tissue engineering due to the demonstrable presence of bioactive components. Different chemical and physical treatments have been employed to enhance the micro-architecture of CMD scaffolds. In this study we have assessed the typical effects of physical cross-linking methods, namely ultraviolet (UV) light, dehydrothermal (DHT) treatment, and combinations of them on bovine articular CMD porous scaffolds with three different matrix concentrations (5%, 15% and 30%) to assess the relative strengths of each treatment. Our findings suggest that UV and UV–DHT treatments on 15% CMD scaffolds can yield architecturally optimal scaffolds for cartilage tissue engineering.

KW - Cartilage matrix

KW - Porous scaffold

KW - Cross-linking

KW - Physical treatment

U2 - 10.1088%2F1468-6996%2F15%2F6%2F065001

DO - 10.1088%2F1468-6996%2F15%2F6%2F065001

M3 - Article

SN - 1468-6996

VL - 15

SP - 1

EP - 12

JO - Science and Technology of Advanced Materials

JF - Science and Technology of Advanced Materials

IS - 6

M1 - 065001

ER -

A comparison study of different physical treatments on cartilage matrix derived porous scaffolds for tissue engineering applications

Abstract

Access to Document

Fingerprint

Cite this