A Mouse Model of Early-Onset Renal Failure Due to a Xanthine Dehydrogenase Nonsense Mutation

Sian E. Piret, Christopher T. Esapa, Caroline M Gorvin, Rosie A Head, Nellie Y. Loh, Olivier Devuyst, Gethin Thomas, Steve D.M. Brown, Matthew Brown, Peter I. Croucher, Roger D. Cox, Rajesh V. Thakker

    Research output: Contribution to journalArticle

    5 Citations (Scopus)
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    Abstract

    Chronic kidney disease (CKD) is characterized by renal fibrosis that can lead to end-stage renal failure, and studies have supported a strong genetic influence on the risk of developing CKD. However, investigations of the underlying molecular mechanisms are hampered by the lack of suitable hereditary models in animals. We therefore sought to establish hereditary mouse models for CKD and renal fibrosis by investigating mice treated with the chemical mutagen N-ethyl-N-nitrosourea, and identified a mouse with autosomal recessive renal failure, designated RENF.
    Original languageEnglish
    Article numbere45217
    Pages (from-to)1-10
    Number of pages10
    JournalPLoS One
    Volume7
    Issue number9
    DOIs
    Publication statusPublished - Sep 2012

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