TY - GEN
T1 - A multiplex device based on tunable nanoshear forces for highly specific detection of multiple protein biomarkers
AU - Vaidyanathan, Ramanathan
AU - Van Leeuwen, Lara Michelle
AU - Rauf, Sakandar
AU - Shiddiky, Muhammad J.A.
AU - Trau, Matt
N1 - Publisher Copyright:
© 14CBMS.
PY - 2014
Y1 - 2014
N2 - We describe a new multiplexed device for the sensitive detection of multiple protein biomarkers in serum by using an alternating current (ac) electrohydrodynamics (ac-EHD) induced surface shear forces based phenomenon referred to as nanoshearing [1,2]. The tunable nature (via manipulation of ac field) of nanoshearing forces can enhance the capture performance of the devices (i.e., enhances the number of sensor-target collisions). This can also selectively displace nonspecifically bound molecules from the electrode surface (i.e., shear forces can be tuned to shear away nonspecific species from biological fluids). To demonstrate the utility and applicability of this phenomenon, we present data on a purpose-built microfluidic device that employs nanoshearing to specifically capture protein biomarkers from complex biological fluids [3].
AB - We describe a new multiplexed device for the sensitive detection of multiple protein biomarkers in serum by using an alternating current (ac) electrohydrodynamics (ac-EHD) induced surface shear forces based phenomenon referred to as nanoshearing [1,2]. The tunable nature (via manipulation of ac field) of nanoshearing forces can enhance the capture performance of the devices (i.e., enhances the number of sensor-target collisions). This can also selectively displace nonspecifically bound molecules from the electrode surface (i.e., shear forces can be tuned to shear away nonspecific species from biological fluids). To demonstrate the utility and applicability of this phenomenon, we present data on a purpose-built microfluidic device that employs nanoshearing to specifically capture protein biomarkers from complex biological fluids [3].
KW - Electrohydrodynamics
KW - Nonspecific adsorption
KW - Protein capture
KW - Surface shear forces
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M3 - Conference paper
AN - SCOPUS:84941702020
T3 - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
SP - 1972
EP - 1974
BT - Proceedings of the 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS)
PB - Chemical and Biological Microsystems Society
T2 - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
Y2 - 26 October 2014 through 30 October 2014
ER -