A multiplex device based on tunable nanoshear forces for highly specific detection of multiple protein biomarkers

Ramanathan Vaidyanathan, Lara Michelle Van Leeuwen, Sakandar Rauf, Muhammad J.A. Shiddiky, Matt Trau

Research output: Book chapter/Published conference paperConference paperpeer-review

Abstract

We describe a new multiplexed device for the sensitive detection of multiple protein biomarkers in serum by using an alternating current (ac) electrohydrodynamics (ac-EHD) induced surface shear forces based phenomenon referred to as nanoshearing [1,2]. The tunable nature (via manipulation of ac field) of nanoshearing forces can enhance the capture performance of the devices (i.e., enhances the number of sensor-target collisions). This can also selectively displace nonspecifically bound molecules from the electrode surface (i.e., shear forces can be tuned to shear away nonspecific species from biological fluids). To demonstrate the utility and applicability of this phenomenon, we present data on a purpose-built microfluidic device that employs nanoshearing to specifically capture protein biomarkers from complex biological fluids [3].

Original languageEnglish
Title of host publicationProceedings of the 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS)
PublisherChemical and Biological Microsystems Society
Pages1972-1974
Number of pages3
ISBN (Electronic)9780979806476
Publication statusPublished - 2014
Event18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States
Duration: 26 Oct 201430 Oct 2014

Publication series

Name18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

Conference

Conference18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
Country/TerritoryUnited States
CitySan Antonio
Period26/10/1430/10/14

Fingerprint

Dive into the research topics of 'A multiplex device based on tunable nanoshear forces for highly specific detection of multiple protein biomarkers'. Together they form a unique fingerprint.

Cite this