TY - JOUR
T1 - A novel endoperoxide and related sesquiterpenes from Artemisia annua which are possibly derived from allylic hydroperoxides
AU - Sy, Lai King
AU - Brown, Geoffrey D.
AU - Haynes, Richard
N1 - Funding Information:
We would like to thank Professor Li Xian-Jun of the Chemistry Department, Sichuan Union University, Chengdu, PRC for kindly providing the A. annua plant material used in this study. This research was funded by a grant from the Bioteehnology Research Institute of Hong Kong.
PY - 1998/4/23
Y1 - 1998/4/23
N2 - Seven novel cadinane sesquiterpenes, including the seven-membered endoperoxide lactone arteannuin H (1), two six-membered lactones arteannuins I (4) and J (5), three five-membered lactones arteannuins K-M (6-8) and a keto acid arteannuin N (9) have been isolated from the dried leaves of Artemisia annua in addition to the known compounds dihydroartemisinic acid (27), dihydroarteannuin B (24) and dihydro-epi-deoxyarteannuin B (22). It is proposed that these novel sesquiterpenes are biogenetically related to dihydroartemisinic acid via intermediate secondary and tertiary allylic hydroperoxides.
AB - Seven novel cadinane sesquiterpenes, including the seven-membered endoperoxide lactone arteannuin H (1), two six-membered lactones arteannuins I (4) and J (5), three five-membered lactones arteannuins K-M (6-8) and a keto acid arteannuin N (9) have been isolated from the dried leaves of Artemisia annua in addition to the known compounds dihydroartemisinic acid (27), dihydroarteannuin B (24) and dihydro-epi-deoxyarteannuin B (22). It is proposed that these novel sesquiterpenes are biogenetically related to dihydroartemisinic acid via intermediate secondary and tertiary allylic hydroperoxides.
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U2 - 10.1016/S0040-4020(98)00148-3
DO - 10.1016/S0040-4020(98)00148-3
M3 - Article
AN - SCOPUS:0032560097
SN - 0040-4020
VL - 54
SP - 4345
EP - 4356
JO - Tetrahedron
JF - Tetrahedron
IS - 17
ER -