A novel retractable device for mapping gastrointestinal slow wave propagation patterns

Rachel Berry, Niranchan Paskaranandavadivel, Peng Du, Mark L. Trew, Gregory O'Grady, John A. Windsor, Leo K. Cheng

    Research output: Contribution to journalArticlepeer-review

    11 Citations (Scopus)

    Abstract

    Background: Gastric slow waves regulate peristalsis, and gastric dysrhythmias have been implicated in functional motility disorders. To accurately define slow wave patterns, it is currently necessary to collect high-resolution serosal recordings during open surgery. We therefore developed a novel gastric slow wave mapping device for use during laparoscopic procedures. Methods: The device consists of a retractable catheter constructed of a flexible nitinol core coated with Pebax. Once deployed through a 5-mm laparoscopic port, the spiral head is revealed with 32 electrodes at 5 mm intervals. Recordings were validated against a reference electrode array in pigs and tested in a human patient. Results: Recordings from the device and a reference array in pigs were identical in frequency (2.6 cycles per minute; p = 0.91), and activation patterns and velocities were consistent (8.9 ± 0.2 vs 8.7 ± 0.1 mm s−1; p = 0.2). Device and reference amplitudes were comparable (1.3 ± 0.1 vs 1.4 ± 0.1 mV; p = 0.4), though the device signal-to-noise ratio was higher (17.5 ± 0.6 vs 12.8 ± 0.6 dB; P < 0.0001). In the human patient, corpus slow waves were recorded and mapped (frequency 2.7 ± 0.03 cycles per minute, amplitude 0.8 ± 0.4 mV, velocity 2.3 ± 0.9 mm s−1). Conclusion: In conclusion, the novel laparoscopic device achieves high-quality serosal slow wave recordings. It can be used for laparoscopic diagnostic studies to document slow wave patterns in patients with gastric motility disorders.
    Original languageEnglish
    Pages (from-to)477-486
    Number of pages10
    JournalSurgical Endoscopy
    Volume31
    Issue number1
    Early online dateApr 2016
    DOIs
    Publication statusPublished - Jan 2017

    Fingerprint

    Dive into the research topics of 'A novel retractable device for mapping gastrointestinal slow wave propagation patterns'. Together they form a unique fingerprint.

    Cite this