A Novel sheep model to study the effect of high rate intracoronary perfusion on cardiac electrophysiology

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Abstract

An increase in coronary flow is known to enhance myocardial metabolism and contractility (the Gregg effect) but the effect on cardiac electrophysiology is unclear. In 5 pentobarbital-anesthetised open-chest sheep, left circumflex coronary artery was perfused with fresh arterial blood at 6 and 10 ml/min respectively in the presence of normal coronary flow. The perfusion was repeated in these animals after treatment with nitro-L-arginine, a nitric oxide synthase inhibitor. The high rate intracoronary perfusion caused a flow-dependent T wave inversion on body surface ECG in all animals (p < 0.01). Pre-treatment with nitro-L-arginine abolished T wave inversion during 6 ml/min perfusion, and diminished the T inversion during 10 ml/min perfusion. Conclusion: An increase in coronary flow alters ventricular repolarisation through nitric oxide release from coronary endothelium.
Original languageEnglish
Pages (from-to)147-151
Number of pages5
JournalGeneral Physiology and Biophysics
Volume21
Issue number2
Publication statusPublished - 2002

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