A preliminary study of possible genetic influences on the susceptibility of sheep to Johne's disease

LA Reddacliff, K. Beh, Helen McGregor, RJ Whittington

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    Abstract

    Objective: To investigate possible genetic influences on susceptibility or resistance of sheep to Johne's disease.Design: A field and laboratory study of two fine-wool Merino flocks with a high prevalence of disease due to Mycobacterium avium subsp paratuberculosis infection.Procedure: Adult sheep were phenotypically classified as having severe, mild or no disease on the basis of clinical, pathological and cultural tests for paratuberculosis, and as positive or negative in tests for humoral immunity (agar gel immunodiffusion test) or cell mediated immunity (skin test for delayed type hyper-sensitivity). Correlations with phenotype were sought for polymorphisms at loci within selected immune function genes (NRAMP, MHC complex, IFN-', lysozyme, leukaemia inhibiting factor).Results: Possible associations of particular NRAMP and MHC alleles with susceptibility or resistance to Johne's disease were detected.Conclusion: If the results of this preliminary study are confirmed in further work, then the use of rams with "resistant" genotypes may assist in the control of Johne's disease in infected flocks.
    Original languageEnglish
    Pages (from-to)435-441
    Number of pages7
    JournalAustralian Veterinary Journal
    Volume83
    Issue number7
    DOIs
    Publication statusPublished - 2005

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