Purpose. To examine the effects of two doses of low-frequency (12 Hz), low-magnitude (0.3 g), whole body vibration on markers of bone formation and resorption in postmenopausal women. Methods. Women were recruited and randomized into a sham vibration control group, one time per week vibration group (1x/week), or three times per week vibration group (3x/week). Vibration exposure consisted of 20 minutes of intermittent vibration for the 1x/week and 3x/week groups, and sham vibration (<0.1 g) for the control group for eight weeks. Double-blinded primary outcome measures were urine markers of bone resorption: N-telopeptide X normalised to creatinine (NTx/Cr) and bone formation: bone-specific alkaline phosphatase (ALP). Results. Forty-six women (59.8 ± 6.2 years, median 7.3 years since menopause) were enrolled. NTx/Cr was significantly reduced (34.6%) in the 3x/wk vibration group but not in the 1x/wk vibration group compared with sham control (P<.01) group. No effect of time or group allocation was observed on the bone formation marker ALP (P=.27). Conclusion. We have shown for the first time that low-frequency, low-magnitude vibration 3x/week for eight weeks in postmenopausal women results in a significant reduction in NTx/Cr, a marker of bone resorption, when compared with sham vibration exposure.
|Number of pages||10|
|Journal||Journal of Osteoporosis|
|Issue number||Article ID 710387|
|Publication status||Published - 2011|