A Randomized Controlled Trial of Whole Body Vibration Exposure on Markers of Bone Turnover in Postmenopausal Women

Sarah Turner, Margaret Torode, Mike Climstein, Geraldine Naughton, David Greene, Michael Baker, Maria A. Fiataraone

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Abstract

Purpose. To examine the effects of two doses of low-frequency (12 Hz), low-magnitude (0.3 g), whole body vibration on markers of bone formation and resorption in postmenopausal women. Methods. Women were recruited and randomized into a sham vibration control group, one time per week vibration group (1x/week), or three times per week vibration group (3x/week). Vibration exposure consisted of 20 minutes of intermittent vibration for the 1x/week and 3x/week groups, and sham vibration (<0.1 g) for the control group for eight weeks. Double-blinded primary outcome measures were urine markers of bone resorption: N-telopeptide X normalised to creatinine (NTx/Cr) and bone formation: bone-specific alkaline phosphatase (ALP). Results. Forty-six women (59.8 ± 6.2 years, median 7.3 years since menopause) were enrolled. NTx/Cr was significantly reduced (34.6%) in the 3x/wk vibration group but not in the 1x/wk vibration group compared with sham control (P<.01) group. No effect of time or group allocation was observed on the bone formation marker ALP (P=.27). Conclusion. We have shown for the first time that low-frequency, low-magnitude vibration 3x/week for eight weeks in postmenopausal women results in a significant reduction in NTx/Cr, a marker of bone resorption, when compared with sham vibration exposure.
Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalJournal of Osteoporosis
Volume2011
Issue numberArticle ID 710387
Publication statusPublished - 2011

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    Turner, S., Torode, M., Climstein, M., Naughton, G., Greene, D., Baker, M., & Fiataraone, M. A. (2011). A Randomized Controlled Trial of Whole Body Vibration Exposure on Markers of Bone Turnover in Postmenopausal Women. Journal of Osteoporosis, 2011(Article ID 710387), 1-10.