A review of paroxysmal sympathetic hyperactivity after acquired brain injury

Iain E. Perkes, Ian J. Baguley, Melissa T. Nott, David L. Menon

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142 Citations (Scopus)

Abstract

Severe excessive autonomic overactivity occurs in a subgroup of people surviving acquired brain injury, themajority of whom show paroxysmal sympathetic and motor overactivity. Delayed recognition of paroxysmal sympathetichyperactivity (PSH) after brain injury may increase morbidity and long-term disability. Despite its significantclinical impact, the scientific literature on this syndrome is confusing; there is no consensus on nomenclature,etiological information for diagnoses preceding the condition is poorly understood, and the evidence base underpinningour knowledge of the pathophysiology and management strategies is largely anecdotal. This systematicliterature review identified 2 separate categories of paroxysmal autonomic overactivity, 1 characterized by relativelypure sympathetic overactivity and another group of disorders with mixed parasympathetic/sympathetic features.The PSH group comprised 349 reported cases, with 79.4% resulting from traumatic brain injury (TBI), 9.7% fromhypoxia, and 5.4% from cerebrovascular accident. Although TBI is the dominant causative etiology, there was somesuggestion that the true incidence of the condition is highest following cerebral hypoxia. In total, 31 differentterms were identified for the condition. Although the most common term in the literature was dysautonomia, theconsistency of sympathetic clinical features suggests that a more specific term should be used. The findings of thisreview suggest that PSH be adopted as a more clinically relevant and appropriate term. The review highlightsmajor problems regarding conceptual definitions, diagnostic criteria, and nomenclature. Consensus on these issuesis recommended as an essential basis for further research in the area.
Original languageEnglish
Pages (from-to)126-135
Number of pages10
JournalAnnals of Neurology
Volume68
Issue number2
Publication statusPublished - 2010

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    Perkes, I. E., Baguley, I. J., Nott, M. T., & Menon, D. L. (2010). A review of paroxysmal sympathetic hyperactivity after acquired brain injury. Annals of Neurology, 68(2), 126-135.