A Rosenthal Fiber Encephalomyelopathy Resembling Alexander's Disease in 3 Sheep

Allan Kessell, J.W. Finnie, J. Manavis, G.D. Cheetham, P.C. Blumbergs

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

We report an encephalomyelopathy in three 18-month-old Merino sheep with features of adult-onset Alexander's disease (AD), a human primary astrocytic disorder. The signature histologic finding was the presence of numerous hypereosinophilic, intra-astrocytic inclusions (Rosenthal fibers), mainly in perivascular, subpial, and subependymal sites, especially in the caudal brain stem and spinal cord. Although AD usually results from mutations in the glial fibrillary acidic protein (GFAP) gene, no such mutation was detected in these sheep. However, the annual clinical presentation of this disorder in a few sheep in the affected flock is suggestive of a familial pattern of occurrence.
Original languageEnglish
Pages (from-to)248-254
Number of pages7
JournalVeterinary Pathology
Volume49
Issue number2
DOIs
Publication statusPublished - 2012

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