A route to prostaglandin precursors from 1-(phenylthio)-2-octenyllithium.

Malcolm R. Binns; Richard K. Haynes; Dale E. Lambert; Paul A. Schober

doi:10.1016/S0040-4039(00)98304-7

A route to prostaglandin precursors from 1-(phenylthio)-2-octenyllithium.

Malcolm R. Binns, Richard K. Haynes, Dale E. Lambert, Paul A. Schober

The University of Sydney

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

The enolates generated by the conjugate addition of 1-(phenylthio)-2-octenyllithium to 4-tert-butoxycyclopent-2-en-1-one and <-crotonolactone react with methyl 7-halohept-5-ynoates in the presence of Ph₃SnCl to deliver products which may be converted into prostaglandin precursors.

Original language	English
Pages (from-to)	3385-3388
Number of pages	4
Journal	Tetrahedron Letters
Volume	26
Issue number	28
DOIs	https://doi.org/10.1016/S0040-4039(00)98304-7
Publication status	Published - 1985

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abstract = "The enolates generated by the conjugate addition of 1-(phenylthio)-2-octenyllithium to 4-tert-butoxycyclopent-2-en-1-one and <-crotonolactone react with methyl 7-halohept-5-ynoates in the presence of Ph3SnCl to deliver products which may be converted into prostaglandin precursors.",

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AB - The enolates generated by the conjugate addition of 1-(phenylthio)-2-octenyllithium to 4-tert-butoxycyclopent-2-en-1-one and <-crotonolactone react with methyl 7-halohept-5-ynoates in the presence of Ph3SnCl to deliver products which may be converted into prostaglandin precursors.

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A route to prostaglandin precursors from 1-(phenylthio)-2-octenyllithium.

Abstract

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