Wildlife health is of emerging relevance for conservation, human health and domestic animal health. Increased research on wildlife health problems has not been accompanied by a relative increase in effective solutions. Translational research was developed in human health to overcome blocks impeding the development of solutions out of basic research, and a translational research framework is proposed to overcome the same barriers in wildlife health. This framework has four translational phases: problem definition; potential solution development; efficacious solution development, and; effective solution development. Implementation of translational research will require a restructuring of the wildlife health research enterprise with 1) a shift, supported by funders and journals, to solutions-focused research including later translational phases, 2) the creation of more deeply integrated multidisciplinary and interdisciplinary teams incorporating better representation from human social sciences, and 3) the inclusion of end-user and stakeholder participation in all phases of research.