A strange family, or how a new pleolipovirus reveals its friends and relatives

Michael Dyall-Smith, Kate Porter

    Research output: Contribution to journalArticlepeer-review

    1 Citation (Scopus)


    A new virus of halophilic Archaea is reported by Liu etal., and is remarkable in many ways. SNJ2 is the first temperate, pleomorphic virus (pleolipovirus) that integrates into the genome of its host. Analyses of the virus structure and its genome have provided an unexpected puzzle while at the same time solving another. On the one hand, the study shows a curious relationship exists between SNJ2 and an unrelated provirus (SNJ1) found as a plasmid in the same cell. The presence of SNJ1 appears to allow much higher levels of SNJ2 virus to be produced, although the mechanism involved remains unclear. On the other hand, the curious occurrence of a conserved cluster of pleolipovirus-related genes found widely distributed among haloarchaeal genomes and known for almost 10 years, now appears to correspond to SNJ2-related proviruses.
    Original languageEnglish
    Pages (from-to)995-997
    Number of pages3
    JournalMolecular Microbiology
    Issue number6
    Publication statusPublished - 2015


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