Abstract
Campylobacter jejuni infection linked
to the consumption of contaminated poultry products is one of the
leading causes of human enteric illness worldwide. Vaccination of
chickens is one of the potential strategies that could be used to
control C. jejuni colonization. To date, various C. jejuni
vaccines using potential antigens have been evaluated, but a challenge
in identifying the most effective formulation is the wide variability in
vaccine efficacies reported. A systematic review was undertaken to
compare C. jejuni vaccine studies.
Based upon specific selection criteria eligible papers were identified
and included in the analysis. Vaccine efficacy reported from different C. jejuni
antigens, vaccine types, and vaccination regimens reported in these
papers were reviewed. Our analysis shows that total outer membrane
proteins and cysteine ABC transporter substrate-binding protein were
among the most efficacious vaccine antigen candidates reported. This
review also highlights the importance of the need for increased
consistency in the way C. jejuni vaccine studies in poultry are designed and reported in order to be able to undertake a robust comparison of C. jejuni vaccine candidates.
Original language | English |
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Article number | 397 |
Pages (from-to) | 1-48 |
Number of pages | 48 |
Journal | Microorganisms |
Volume | 9 |
Issue number | 2 |
DOIs | |
Publication status | Published - Feb 2021 |