A systems biology approach to identifying genetic markers that link progression of Parkinson's Disease to risk factors related to ageing, lifestyle and Type 2 diabetes

Najmus Sakib, Utpala Nanda Chowdhury, M. Babul Islam, Fazlul Huq, Julian M.W. Quinn, Mohammad Ali Moni

Research output: Book chapter/Published conference paperConference paperpeer-review

3 Citations (Scopus)

Abstract

The processes that underlie Parkinsons disease (PD) are still unclear, but improved comprehension of genetic and environmental influences on PD, and how these influences interact will help find new approaches to reducing PD progression. We thus employed quantitative framework analysis to reveal some of the complex relationship of various genetic factors affecting PD. In this study, we analyzed gene expression microarray data from cells and tissues affected by PD, ageing (AG), type II diabetes (T2D), high body fat (HBF) and control datasets. We determined genetic associations of PD and these risk factors based on neighborhood-based benchmarking and multilayer network topology. We first identified 1343 significantly dysregulated genes in the PD patient tissues compared to healthy control, including we have 779 genes with down regulated expression and 544 genes up regulated. 45 genes were highly expressed in both for the PD and ageing; the number of shared genes for the PD and the type II diabetes is 51. Ontological and pathway analyses then identified significant gene ontology and molecular pathways that enhance our understanding of the fundamental molecular procedure of the PD progression. Therapeutic targets of the PD could be developed using these identified target genes, ontologies and pathways.

Original languageEnglish
Title of host publication5th International Conference on Computer, Communication, Chemical, Materials and Electronic Engineering, IC4ME2 2019
PublisherIEEE, Institute of Electrical and Electronics Engineers
Number of pages5
ISBN (Electronic)9781728130606
ISBN (Print)9781728130613
DOIs
Publication statusPublished - Jul 2019
Event5th International Conference on Computer, Communication, Chemical, Materials and Electronic Engineering, IC4ME2 2019 - University of Rajshahi, Rajshahi, Bangladesh
Duration: 11 Jul 201912 Jul 2019
https://web.archive.org/web/20191028191905/http://dept.ru.ac.bd/ic4me2/2019/ (Wayback Machine link to conference website)
https://web.archive.org/web/20191030061438/http://dept.ru.ac.bd/ic4me2/2019/?page_id=115 (Call for papers)

Publication series

Name5th International Conference on Computer, Communication, Chemical, Materials and Electronic Engineering, IC4ME2 2019

Conference

Conference5th International Conference on Computer, Communication, Chemical, Materials and Electronic Engineering, IC4ME2 2019
Country/TerritoryBangladesh
CityRajshahi
Period11/07/1912/07/19
OtherThe International Conference on Computer, Communication, Chemical, Material and Electronic Engineering (IC4ME2-2019) will be held from July 11~12, 2019 at University of Rajshahi in Bangladesh. This conference is a sequel of our first conference ICMEIE-2015. The conference will gather world-class researchers, engineers and educators engaged in the fields of Materials, Electronics, Chemical and Information Engineering to meet and present their latest activities. The main theme of this conference is Networking and Collaboration.
Internet address

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