Abdominal giant lymph node hyperplasia (Castleman's disease): report of two cases

Objective: To describe the clinical characteristics and diagnostic features of giant lymph node hyperplasia or Castleman's diseasefound in rare locations. Methods: Two cases of Castleman's disease (1 abdominal and 1 retroperitoneal) were confirmed histopathologically.The clinical and medical imaging features were described and relative literatures were reviewed. Results: One patient had noclinical symptoms and the other had epigastric discomfort. The location of the benign tumor was retroperitoneal and left adrenal gland,respectively. Both cases were of solitary tumor, 1 was a hyaline-vascular type and the other was a mixed type with plasma cell andhyaline-vascular type. Both were successfully treated by surgical excision. Patients were followed up for 3 and 4 years respectivelywith no signs of recurrence on CT imaging.Conclusions: Abdominal Castleman’s disease lacks specific clinical manifestations. Definitive diagnosis requires histologic examination and excisional surgery is the method of choice for treatment