Abrogation of the interferon response promotes more efficient human cytomegalovirus replication

Brian P McSharry, Simone K Forbes, Selmir Avdic, Richard E Randall, Gavin W G Wilkinson, Allison Abendroth, Barry Slobedman

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

The effect of abrogating the interferon (IFN) response on human cytomegalovirus (HCMV) replication was investigated using primary human cells engineered to block either the production of or the response to type I IFNs. In IFN-deficient cells, HCMV produced larger plaques and spread and replicated more rapidly than in parental cells. These cells demonstrate the vital role of IFNs in controlling HCMV replication and provide useful tools to investigate the IFN response to HCMV.

Original languageEnglish
Pages (from-to)1479-1483
Number of pages5
JournalJournal of Virology
Volume89
Issue number2
DOIs
Publication statusPublished - 15 Jan 2015

Fingerprint

Dive into the research topics of 'Abrogation of the interferon response promotes more efficient human cytomegalovirus replication'. Together they form a unique fingerprint.

Cite this