Acquired inhibitors of coagulation factors: part II

Massimo Franchini, Giuseppe Lippi, Emmanuel J Favaloro

Research output: Contribution to journalReview articlepeer-review

45 Citations (Scopus)


Acquired coagulation inhibitors are antibodies that bind to coagulation factors and neutralize their activity or accelerate their clearance. Inhibitors occurring in patients with inherited deficiencies of coagulation factors are referred to as "alloantibodies," while those developing spontaneously in individuals with previously normal coagulation factor function are designated as "autoantibodies." The latter category includes inhibitors against coagulation factors I, II, V, VII, VIII (acquired hemophilia A), IX (acquired hemophilia B), X, XI, and XIII. This review will discuss the most important pathogenic, clinical, laboratory, and therapeutic aspects of the inhibitors of coagulation factors other than acquired hemophilia A, as this is reviewed separately within this issue of the journal.

Original languageEnglish
Pages (from-to)447-453
Number of pages7
JournalSeminars in Thrombosis and Hemostasis
Issue number5
Publication statusPublished - Jul 2012


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