Acute changes in handgrip strength, lung function and health-related quality of life following cardiac surgery

Nnamdi Mgbemena, Anne Jones, Pankaj Saxena, Nicholas Ang, Siva Senthuran, Anthony Leicht

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)
3 Downloads (Pure)


Handgrip strength (HGS), lung function and health-related quality of life (HRQoL) are relevant indicators of future cardiovascular risk and mortality. The impact of cardiac surgery on these predictive variables has been under-explored. The aim of this study was to determine the acute (within hospital) changes in HGS, lung function and HRQoL, and their relationships, in adults undergoing elective cardiac surgery. Further, the study examined the relationship between these variables and the predictors for lung function and HRQoL in these patients.

The study was a prospective cohort study that involved 101 patients who completed pre-operative (1–2 days before surgery) and physiotherapy discharge (5–7 days after surgery) assessments. Handgrip strength, lung function and HRQoL were assessed using JAMAR dynamometers, Vitalograph-Alpha or EasyOne spirometer, and Short-Form 36 questionnaire, respectively. Changes in these variables and their relationships were analysed using paired t-test and Pearson correlation coefficients, respectively. Prediction of lung function and HRQoL using HGS and other co-variates was conducted using regression analysis.

At the time of physiotherapy discharge, lung function, HGS and the physical component of HRQoL were significantly (
Undergoing cardiac surgery acutely and significantly reduced lung function, HGS and physical component of HRQoL in adults with cardiac disease. Assessment of HGS at physiotherapy discharge may be a poor indicator of operative changes in lung function and HRQoL. Clinicians may consider HGS as an inadequate tool in predicting lung function and HRQoL following cardiac surgery.
Original languageEnglish
Article numbere0263683
Number of pages13
JournalPLoS One
Issue number2
Publication statusPublished - 23 Feb 2022
Externally publishedYes


Dive into the research topics of 'Acute changes in handgrip strength, lung function and health-related quality of life following cardiac surgery'. Together they form a unique fingerprint.

Cite this