An allelopathic compound from festuca spp. as a lead molecule for development of pre-emergent herbicides for weed management

Craig Stewart; Russell Barrow; Sajid Latif; Leslie A. Weston

Abstract

There is a great need for the development of herbicides with novel modes of action, due to increasing evolution of herbicide resistance in common weed species and the lack new modes of action in commercial herbicides introduced in recent years.1-3 Certain cultivars of fine leaved fescue (Festuca spp.) grasses are known to interfere with the growth of other plants by exudation of a phytotoxic non-protein amino acid, m-tyrosine, into the rhizosphere.4,5 However, m-tyrosine is highly susceptible to microbial degradation and so is potentially unsuited for use as a commercial soil-applied pre-emergence herbicide. We have synthesised several analogues based on the bioactive architecture of this natural product, with improved herbicidal activity and will evaluate extended environmental half-life, and investigate potential mode(s) of action.

Original language	English
Pages	314
Number of pages	1
Publication status	Published - 10 Aug 2018
Event	34th Annual Meeting of the International Society of Chemical Ecology - Budapest Congress Center, Budapest, Hungary Duration: 12 Aug 2018 → 18 Aug 2018 https://www.chemecol.org/pastmeetings.shtml

Conference

Conference	34th Annual Meeting of the International Society of Chemical Ecology
Country	Hungary
City	Budapest
Period	12/08/18 → 18/08/18
Internet address	https://www.chemecol.org/pastmeetings.shtml

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title = "An allelopathic compound from festuca spp. as a lead molecule for development of pre-emergent herbicides for weed management",

abstract = "There is a great need for the development of herbicides with novel modes of action, due to increasing evolution of herbicide resistance in common weed species and the lack new modes of action in commercial herbicides introduced in recent years.1-3 Certain cultivars of fine leaved fescue (Festuca spp.) grasses are known to interfere with the growth of other plants by exudation of a phytotoxic non-protein amino acid, m-tyrosine, into the rhizosphere.4,5 However, m-tyrosine is highly susceptible to microbial degradation and so is potentially unsuited for use as a commercial soil-applied pre-emergence herbicide. We have synthesised several analogues based on the bioactive architecture of this natural product, with improved herbicidal activity and will evaluate extended environmental half-life, and investigate potential mode(s) of action.",

author = "Craig Stewart and Russell Barrow and Sajid Latif and Weston, {Leslie A.}",

year = "2018",

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day = "10",

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An allelopathic compound from festuca spp. as a lead molecule for development of pre-emergent herbicides for weed management. / Stewart, Craig; Barrow, Russell; Latif, Sajid ; Weston, Leslie A.

2018. 314 Abstract from 34th Annual Meeting of the International Society of Chemical Ecology, Budapest, Hungary.

Research output: Other contribution to conference › Abstract › peer-review

TY - CONF

T1 - An allelopathic compound from festuca spp. as a lead molecule for development of pre-emergent herbicides for weed management

AU - Stewart, Craig

AU - Barrow, Russell

AU - Latif, Sajid

AU - Weston, Leslie A.

PY - 2018/8/10

Y1 - 2018/8/10

N2 - There is a great need for the development of herbicides with novel modes of action, due to increasing evolution of herbicide resistance in common weed species and the lack new modes of action in commercial herbicides introduced in recent years.1-3 Certain cultivars of fine leaved fescue (Festuca spp.) grasses are known to interfere with the growth of other plants by exudation of a phytotoxic non-protein amino acid, m-tyrosine, into the rhizosphere.4,5 However, m-tyrosine is highly susceptible to microbial degradation and so is potentially unsuited for use as a commercial soil-applied pre-emergence herbicide. We have synthesised several analogues based on the bioactive architecture of this natural product, with improved herbicidal activity and will evaluate extended environmental half-life, and investigate potential mode(s) of action.

AB - There is a great need for the development of herbicides with novel modes of action, due to increasing evolution of herbicide resistance in common weed species and the lack new modes of action in commercial herbicides introduced in recent years.1-3 Certain cultivars of fine leaved fescue (Festuca spp.) grasses are known to interfere with the growth of other plants by exudation of a phytotoxic non-protein amino acid, m-tyrosine, into the rhizosphere.4,5 However, m-tyrosine is highly susceptible to microbial degradation and so is potentially unsuited for use as a commercial soil-applied pre-emergence herbicide. We have synthesised several analogues based on the bioactive architecture of this natural product, with improved herbicidal activity and will evaluate extended environmental half-life, and investigate potential mode(s) of action.

M3 - Abstract

SP - 314

T2 - 34th Annual Meeting of the International Society of Chemical Ecology

Y2 - 12 August 2018 through 18 August 2018

ER -