An examination of the association of serum IGF-I concentration, potential candidate genes, and fiber type composition with variation in residual feed intake in progeny of Red Angus sires divergent for maintenance energy EPD

CM Welch, KJ Thornton, GK Murdoch, KC Chapalamadugu, CS Schneider, JK Ahola, JB Hall, WJ Price, RA Hill

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Abstract

Investigating the genetic and physiological drivers of postweaning residual feed intake (RFI) and finishing phase feed efficiency (FE) may identify underlying mechanisms that are responsible for the variation in these complex FE traits. The objectives were 1) to evaluate the relationship of serum IGF-I concentration and muscle gene expression with postweaning RFI and sire maintenance energy (MEM) EPD and 2) to determine fiber type composition as it relates to postweaning RFI and finishing phase FE. Results indicate that RFI and serum IGF-I concentration were not associated (P > 0.05); however, negative correlations (P <0.05) between sire MEM EPD and serum IGF-I concentration were observed. Gene expression differences between high-and low-RFI animals were observed in cohort 1, where IGFBP5 expression was greater (P <0.05) in high-RFI animals. When animals were grouped according to sire MEM EPD, the low MEM EPD group of cohort 1 showed greater muscle mRNA expression (P <0.01) of fatty acid synthase (FASN) and marginally (P <0.10) greater expression of IGFBP5 and C/EBP alpha (C/EBP alpha) whereas the high MEM EPD group of cohort 2 had greater muscle mRNA expression of IGFBP2 (P <0.05) and C/EBP alpha (P
Original languageEnglish
Pages (from-to)5626-5636
Number of pages11
JournalJournal of Animal Science
Volume91
Issue number12
Early online dateOct 2013
DOIs
Publication statusPublished - Dec 2013

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Red Angus
CCAAT-Enhancer-Binding Protein-alpha
insulin-like growth factor I
Insulin-Like Growth Factor I
sires
feed intake
Maintenance
Muscles
energy
Serum
Genes
Gene Expression
Fatty Acid Synthases
Messenger RNA
genes
feed conversion
muscles
finishing
gene expression
animals

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title = "An examination of the association of serum IGF-I concentration, potential candidate genes, and fiber type composition with variation in residual feed intake in progeny of Red Angus sires divergent for maintenance energy EPD",
abstract = "Investigating the genetic and physiological drivers of postweaning residual feed intake (RFI) and finishing phase feed efficiency (FE) may identify underlying mechanisms that are responsible for the variation in these complex FE traits. The objectives were 1) to evaluate the relationship of serum IGF-I concentration and muscle gene expression with postweaning RFI and sire maintenance energy (MEM) EPD and 2) to determine fiber type composition as it relates to postweaning RFI and finishing phase FE. Results indicate that RFI and serum IGF-I concentration were not associated (P > 0.05); however, negative correlations (P <0.05) between sire MEM EPD and serum IGF-I concentration were observed. Gene expression differences between high-and low-RFI animals were observed in cohort 1, where IGFBP5 expression was greater (P <0.05) in high-RFI animals. When animals were grouped according to sire MEM EPD, the low MEM EPD group of cohort 1 showed greater muscle mRNA expression (P <0.01) of fatty acid synthase (FASN) and marginally (P <0.10) greater expression of IGFBP5 and C/EBP alpha (C/EBP alpha) whereas the high MEM EPD group of cohort 2 had greater muscle mRNA expression of IGFBP2 (P <0.05) and C/EBP alpha (P",
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author = "CM Welch and KJ Thornton and GK Murdoch and KC Chapalamadugu and CS Schneider and JK Ahola and JB Hall and WJ Price and RA Hill",
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An examination of the association of serum IGF-I concentration, potential candidate genes, and fiber type composition with variation in residual feed intake in progeny of Red Angus sires divergent for maintenance energy EPD. / Welch, CM; Thornton, KJ; Murdoch, GK; Chapalamadugu, KC; Schneider, CS; Ahola, JK; Hall, JB; Price, WJ; Hill, RA.

In: Journal of Animal Science, Vol. 91, No. 12, 12.2013, p. 5626-5636.

Research output: Contribution to journalArticle

TY - JOUR

T1 - An examination of the association of serum IGF-I concentration, potential candidate genes, and fiber type composition with variation in residual feed intake in progeny of Red Angus sires divergent for maintenance energy EPD

AU - Welch, CM

AU - Thornton, KJ

AU - Murdoch, GK

AU - Chapalamadugu, KC

AU - Schneider, CS

AU - Ahola, JK

AU - Hall, JB

AU - Price, WJ

AU - Hill, RA

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DO - 10.2527/jas.2013-6609

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SN - 0021-8812

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