An examination of the association of serum IGF-I concentration, potential candidate genes, and fiber type composition with variation in residual feed intake in progeny of Red Angus sires divergent for maintenance energy EPD

CM Welch; KJ Thornton; GK Murdoch; KC Chapalamadugu; CS Schneider; JK Ahola; JB Hall; WJ Price; RA Hill

doi:10.2527/jas.2013-6609

An examination of the association of serum IGF-I concentration, potential candidate genes, and fiber type composition with variation in residual feed intake in progeny of Red Angus sires divergent for maintenance energy EPD

CM Welch, KJ Thornton, GK Murdoch, KC Chapalamadugu, CS Schneider, JK Ahola, JB Hall, WJ Price, RA Hill

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

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Abstract

Investigating the genetic and physiological drivers of postweaning residual feed intake (RFI) and finishing phase feed efficiency (FE) may identify underlying mechanisms that are responsible for the variation in these complex FE traits. The objectives were 1) to evaluate the relationship of serum IGF-I concentration and muscle gene expression with postweaning RFI and sire maintenance energy (MEM) EPD and 2) to determine fiber type composition as it relates to postweaning RFI and finishing phase FE. Results indicate that RFI and serum IGF-I concentration were not associated (P > 0.05); however, negative correlations (P <0.05) between sire MEM EPD and serum IGF-I concentration were observed. Gene expression differences between high-and low-RFI animals were observed in cohort 1, where IGFBP5 expression was greater (P <0.05) in high-RFI animals. When animals were grouped according to sire MEM EPD, the low MEM EPD group of cohort 1 showed greater muscle mRNA expression (P <0.01) of fatty acid synthase (FASN) and marginally (P <0.10) greater expression of IGFBP5 and C/EBP alpha (C/EBP alpha) whereas the high MEM EPD group of cohort 2 had greater muscle mRNA expression of IGFBP2 (P <0.05) and C/EBP alpha (P

Original language	English
Pages (from-to)	5626-5636
Number of pages	11
Journal	Journal of Animal Science
Volume	91
Issue number	12
Early online date	Oct 2013
DOIs	https://doi.org/10.2527/jas.2013-6609
Publication status	Published - Dec 2013

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Welch, CM., Thornton, KJ., Murdoch, GK., Chapalamadugu, KC., Schneider, CS., Ahola, JK., Hall, JB., Price, WJ., & Hill, RA. (2013). An examination of the association of serum IGF-I concentration, potential candidate genes, and fiber type composition with variation in residual feed intake in progeny of Red Angus sires divergent for maintenance energy EPD. Journal of Animal Science, 91(12), 5626-5636. https://doi.org/10.2527/jas.2013-6609

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title = "An examination of the association of serum IGF-I concentration, potential candidate genes, and fiber type composition with variation in residual feed intake in progeny of Red Angus sires divergent for maintenance energy EPD",

abstract = "Investigating the genetic and physiological drivers of postweaning residual feed intake (RFI) and finishing phase feed efficiency (FE) may identify underlying mechanisms that are responsible for the variation in these complex FE traits. The objectives were 1) to evaluate the relationship of serum IGF-I concentration and muscle gene expression with postweaning RFI and sire maintenance energy (MEM) EPD and 2) to determine fiber type composition as it relates to postweaning RFI and finishing phase FE. Results indicate that RFI and serum IGF-I concentration were not associated (P > 0.05); however, negative correlations (P <0.05) between sire MEM EPD and serum IGF-I concentration were observed. Gene expression differences between high-and low-RFI animals were observed in cohort 1, where IGFBP5 expression was greater (P <0.05) in high-RFI animals. When animals were grouped according to sire MEM EPD, the low MEM EPD group of cohort 1 showed greater muscle mRNA expression (P <0.01) of fatty acid synthase (FASN) and marginally (P <0.10) greater expression of IGFBP5 and C/EBP alpha (C/EBP alpha) whereas the high MEM EPD group of cohort 2 had greater muscle mRNA expression of IGFBP2 (P <0.05) and C/EBP alpha (P ",

keywords = "beef cattle, fiber type, gene expression, IGF-I, maintenance energy, residual feed intake",

author = "CM Welch and KJ Thornton and GK Murdoch and KC Chapalamadugu and CS Schneider and JK Ahola and JB Hall and WJ Price and RA Hill",

year = "2013",

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doi = "10.2527/jas.2013-6609",

language = "English",

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pages = "5626--5636",

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Welch, CM, Thornton, KJ, Murdoch, GK, Chapalamadugu, KC, Schneider, CS, Ahola, JK, Hall, JB, Price, WJ & Hill, RA 2013, 'An examination of the association of serum IGF-I concentration, potential candidate genes, and fiber type composition with variation in residual feed intake in progeny of Red Angus sires divergent for maintenance energy EPD', Journal of Animal Science, vol. 91, no. 12, pp. 5626-5636. https://doi.org/10.2527/jas.2013-6609

An examination of the association of serum IGF-I concentration, potential candidate genes, and fiber type composition with variation in residual feed intake in progeny of Red Angus sires divergent for maintenance energy EPD. / Welch, CM; Thornton, KJ; Murdoch, GK et al.
In: Journal of Animal Science, Vol. 91, No. 12, 12.2013, p. 5626-5636.

Research output: Contribution to journal › Article › peer-review

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T1 - An examination of the association of serum IGF-I concentration, potential candidate genes, and fiber type composition with variation in residual feed intake in progeny of Red Angus sires divergent for maintenance energy EPD

AU - Welch, CM

AU - Thornton, KJ

AU - Murdoch, GK

AU - Chapalamadugu, KC

AU - Schneider, CS

AU - Ahola, JK

AU - Hall, JB

AU - Price, WJ

AU - Hill, RA

PY - 2013/12

Y1 - 2013/12

N2 - Investigating the genetic and physiological drivers of postweaning residual feed intake (RFI) and finishing phase feed efficiency (FE) may identify underlying mechanisms that are responsible for the variation in these complex FE traits. The objectives were 1) to evaluate the relationship of serum IGF-I concentration and muscle gene expression with postweaning RFI and sire maintenance energy (MEM) EPD and 2) to determine fiber type composition as it relates to postweaning RFI and finishing phase FE. Results indicate that RFI and serum IGF-I concentration were not associated (P > 0.05); however, negative correlations (P <0.05) between sire MEM EPD and serum IGF-I concentration were observed. Gene expression differences between high-and low-RFI animals were observed in cohort 1, where IGFBP5 expression was greater (P <0.05) in high-RFI animals. When animals were grouped according to sire MEM EPD, the low MEM EPD group of cohort 1 showed greater muscle mRNA expression (P <0.01) of fatty acid synthase (FASN) and marginally (P <0.10) greater expression of IGFBP5 and C/EBP alpha (C/EBP alpha) whereas the high MEM EPD group of cohort 2 had greater muscle mRNA expression of IGFBP2 (P <0.05) and C/EBP alpha (P

AB - Investigating the genetic and physiological drivers of postweaning residual feed intake (RFI) and finishing phase feed efficiency (FE) may identify underlying mechanisms that are responsible for the variation in these complex FE traits. The objectives were 1) to evaluate the relationship of serum IGF-I concentration and muscle gene expression with postweaning RFI and sire maintenance energy (MEM) EPD and 2) to determine fiber type composition as it relates to postweaning RFI and finishing phase FE. Results indicate that RFI and serum IGF-I concentration were not associated (P > 0.05); however, negative correlations (P <0.05) between sire MEM EPD and serum IGF-I concentration were observed. Gene expression differences between high-and low-RFI animals were observed in cohort 1, where IGFBP5 expression was greater (P <0.05) in high-RFI animals. When animals were grouped according to sire MEM EPD, the low MEM EPD group of cohort 1 showed greater muscle mRNA expression (P <0.01) of fatty acid synthase (FASN) and marginally (P <0.10) greater expression of IGFBP5 and C/EBP alpha (C/EBP alpha) whereas the high MEM EPD group of cohort 2 had greater muscle mRNA expression of IGFBP2 (P <0.05) and C/EBP alpha (P

KW - beef cattle

KW - fiber type

KW - gene expression

KW - IGF-I

KW - maintenance energy

KW - residual feed intake

U2 - 10.2527/jas.2013-6609

DO - 10.2527/jas.2013-6609

M3 - Article

C2 - 24085409

SN - 0021-8812

VL - 91

SP - 5626

EP - 5636

JO - Journal of Animal Science

JF - Journal of Animal Science

IS - 12

ER -

Welch CM, Thornton KJ, Murdoch GK, Chapalamadugu KC, Schneider CS, Ahola JK et al. An examination of the association of serum IGF-I concentration, potential candidate genes, and fiber type composition with variation in residual feed intake in progeny of Red Angus sires divergent for maintenance energy EPD. Journal of Animal Science. 2013 Dec;91(12):5626-5636. Epub 2013 Oct. doi: 10.2527/jas.2013-6609