An idea to explore: Visualization of ionization of amino acids using Mathematica

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Abstract

Ionization of amino acids (AA) is very important concept in biochemistry. We
integrate the mathematical concept of probability with biochemically relevant
process of AA ionization. We visualize the ionization process with Mathematica
software discussing intramolecular interactions between weakly acidic/basic functional groups and charge–pH variation of amino acids in water solution. The visualizations rely on the notion of probability of ionization of functional groups and demonstrate how the extent of ionization and charge varies with pH of the solution. The examples described include amino acids and weak diprotic acids and
bases. The aim is to help students better appreciate the importance and consequences of AA ionization and correct some misconceptions.
Original languageEnglish
Pages (from-to)333-345
Number of pages13
JournalBiochemistry and Molecular Biology Education
Volume49
Issue number3
Early online date23 Oct 2020
DOIs
Publication statusPublished - May 2021

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