An overview of laboratory testing for antiphospholipid antibodies

Emmanuel J Favaloro, Leonardo Pasalic

Research output: Book chapter/Published conference paperChapter (peer-reviewed)peer-review

2 Citations (Scopus)


Antiphospholipid antibodies (aPL) represent a group of autoantibodies directed against phospholipids. These antibodies may arise in a number of autoimmune conditions, of which the antiphospholipid (antibody) syndrome (APS) is best recognized. aPL can be detected by various laboratory assays, essentially comprising both solid-phase (immunological) assays and "liquid-phase" clotting assays identifying so-called lupus anticoagulants (LA). aPL are associated with various adverse pathologies, including thrombosis and placental/fetal morbidity and mortality. The type of aPL present, as well as the pattern of reactivity, is variously associated with the severity of the pathology. Thus, laboratory testing for aPL is indicated to help assess the future risk of such events, as well as representing certain "classification" criteria for APS, also used as surrogates for diagnostic criteria. The current chapter overviews the laboratory tests available to measure aPL and their potential clinical utility.
Original languageEnglish
Title of host publicationHemostasis and thrombosis
Subtitle of host publicationMethods and protocols
EditorsEmmanuel J. Favaloro , Robert C. Gosselin
Place of PublicationNew York
PublisherHumana Press
Number of pages10
ISBN (Electronic)9781071631751
ISBN (Print)9781071631744
Publication statusPublished - 2023

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029


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