Analysis of urine cytology tests in 120 paired cases

Khar-Kee Sng, Min En Nga, Soo-yong Tan, Todd Walker

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

ObjectiveTo evaluate the smear quality and diagnostic accuracy of ThinPrep processing in,comparison to conventional Cytospin technique for urinary cytology.Study DesignThinPrep and Cytospin techniques were retrospectively evaluated by 2 observers in a double-blinded, randomized fashion. Each quality parameter was scored using a semi-quantitative score of 1-3. Diagnostic accuracy indices were calculated with biopsy histology as the gold standard.ResultsQuality of cellular distribution and cell preservation were better with Cytospin preparations, whereas ThinPrep smears were superior in terms of stain distribution and cleaner slide background. However, the only significant differences observed were in cellular distribution and a clean background (p < 0.05). Sensitivity and positive and negative predictive values were higher with Cytospin than the ThinPrep technique (90.0%, 94.7% and 71.4% vs. 80.0%, 94.1% and 55.6%, respectively). Conversely, the specificity of both techniques was comparable.ConclusionThe Cytospin smears were of better quality than those prepared by the ThinPrep technique. Although both techniques resulted in similar diagnostic accuracies in negative cases, the ThinPrep preparations were not found to be superior to Cytospin smears in diagnosing positive urinary cytology.
Original languageEnglish
Pages (from-to)782-787
Number of pages6
JournalActa Cytologica
Volume51
Issue number5
Publication statusPublished - 2007

Fingerprint Dive into the research topics of 'Analysis of urine cytology tests in 120 paired cases'. Together they form a unique fingerprint.

  • Cite this

    Sng, K-K., Nga, M. E., Tan, S., & Walker, T. (2007). Analysis of urine cytology tests in 120 paired cases. Acta Cytologica, 51(5), 782-787.