Andexanet: Effectively reversing anticoagulation

Giuseppe Lippi, Fabian Sanchis-Gomar, Emmanuel J Favaloro

Research output: Contribution to journalReview articlepeer-review

7 Citations (Scopus)


Despite direct oral anticoagulants becoming a mainstay of anticoagulant therapy, the effective, timely, and safe reversal of their anticoagulant effect remains challenging. Emerging evidence attests that andexanet, a recombinant and inactive variant of native factor X (FXa), competitively inhibits and counteracts the anticoagulant effect of many inhibitors of native activated FXa.

Original languageEnglish
Pages (from-to)413-414
Number of pages2
JournalTrends in Pharmacological Sciences
Issue number6
Publication statusPublished - Jun 2016


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