TY - JOUR
T1 - Animal venoms as potential source of anticonvulsants
AU - Zainal Abidin, Syafiq Asnawi
AU - Liew, Anthony Kin Yip
AU - Othman, Iekhsan
AU - Shaikh, Farooq
N1 - Publisher Copyright:
Copyright: © 2024 Zainal Abidin SA et al.
PY - 2024
Y1 - 2024
N2 - Epilepsy affects millions of people worldwide, and there is an urgent need to develop safe and effective therapeutic agents. Animal venoms contain diverse bioactive compounds like proteins, peptides, and small molecules, which may possess medicinal properties against epilepsy. In recent years, research has shown that venoms from various organisms such as spiders, ants, bees, wasps, and conus snails have anticonvulsant and antiepileptic effects by targeting specific receptors and ion channels. This review underscores the significance of purified proteins and toxins from these sources as potential therapeutic agents for epilepsy. In conclusion, this review emphasizes the valuable role of animal venoms as a natural resource for further exploration in epilepsy treatment research.
AB - Epilepsy affects millions of people worldwide, and there is an urgent need to develop safe and effective therapeutic agents. Animal venoms contain diverse bioactive compounds like proteins, peptides, and small molecules, which may possess medicinal properties against epilepsy. In recent years, research has shown that venoms from various organisms such as spiders, ants, bees, wasps, and conus snails have anticonvulsant and antiepileptic effects by targeting specific receptors and ion channels. This review underscores the significance of purified proteins and toxins from these sources as potential therapeutic agents for epilepsy. In conclusion, this review emphasizes the valuable role of animal venoms as a natural resource for further exploration in epilepsy treatment research.
KW - Animal Venom
KW - Anticonvulsant
KW - Bioactive Compounds
KW - Epilepsy
KW - GABA
KW - NMDA
UR - http://www.scopus.com/inward/record.url?scp=85196759813&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85196759813&partnerID=8YFLogxK
U2 - 10.12688/f1000research.147027.1
DO - 10.12688/f1000research.147027.1
M3 - Review article
C2 - 38919947
AN - SCOPUS:85196759813
SN - 2046-1402
VL - 13
JO - F1000Research
JF - F1000Research
M1 - 225
ER -