ANKH polymorphisms and clicking of the temporomandibular joint in dental residents

Boyen Huang, Katsu Takahashi, Tomoko Goto, Honoka Kiso, Manabu Sugai, Akira Shimizu, Shinji Kosugi, Kazuhisa Bessho

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Aim: This study aimed to carry out a case-control research study to assess occurrence of clicking of the temporomandibular joint (TMJ) in order to establish the relationship between TMJ clicking and the genotype of "ANKH inorganic pyrophosphate transport regulator'' (ANKH) polymorphisms. Materials and Method: A sample of 41 first-year dental residents was selected. Each was examined using standard clinical procedures and genotyping techniques.Results The participation rate was 91.8 %. The prevalence of TMJ clicking was 51.2 % (95 % CI: 35.7-66.7 %). Occurrence of TMJ clicking was not related to age, gender and genotypes of ANKH-OR as well as ANKH-TR polymorphisms (p >= 0.165). Conclusion: A similar distribution of ANKH genotypes in TMJ clicking and asymptomatic individuals has been demonstrated by this study. A high percentage of TMJ clicking has been confirmed. Future investigations are indicated.
Original languageEnglish
Pages (from-to)247-251
Number of pages5
JournalJournal of Maxillofacial and Oral Surgery
Issue number2
Early online date2014
Publication statusPublished - Jun 2015


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