Anti-adipogenic properties of canola meal extracts

Saira Hussain, Ata Rehman, David Luckett, Christopher Blanchard, Hassan Obied, Padraig Strappe

Research output: Other contribution to conferenceAbstract

Abstract

Canola meal is a low value by-product of canola processing. Extracts from canola meal have the potential to be used as a functional food ingredients as they contain compounds such as phenolic acids which have been shown to have human health benefits. In this study, water (WE) and various 80% organic solvent/water mixtures: methanol (ME), acetone (AE), ethanol (EE), butanol (BE), chloroform (CE) and hexane (HE) were evaluated for their ability to extract compounds from canola meal that have in vitro anti-obesity properties. Anti-obesity properties were studied using adipogenic differentiation inhibition of a murine mesenchymal stem cell line (C3H10T1/2) and a pancreatic lipase inhibition assay. AE, ME and BE gave rise to a marked reduction (p<0.05) for both adipogenesis and pancreatic lipase activity. AE was shown to down-regulate the gene expression of a major adipogenic transcription factor, peroxisome proliferator-activated receptor gamma (PPARγ). Furthermore, the characterization of AE revealed high recovery of phenols such as sinapine, ferroyl choline guiacyl and other sinapic acid and kaempferol derivatives which are known to be associated with adipogenesis inhibition.
Original languageEnglish
Pages108
Number of pages1
Publication statusPublished - 12 Sep 2018
Event68th Australasian Grain Science Conference - Charles Sturt University, Wagga Wagga, Australia
Duration: 10 Sep 201813 Sep 2018
https://www.ausgrainscience.org.au/wp-content/uploads/Conference2018/Booklet-2018.pdf (Conference booklet)

Conference

Conference68th Australasian Grain Science Conference
Abbreviated titleGrain Science Transforming our Future
Country/TerritoryAustralia
CityWagga Wagga
Period10/09/1813/09/18
Internet address

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