Anti-cancer properties of Lupin Peptide Hydrolysate

Research output: Other contribution to conferencePoster

Abstract

Lupin seeds are rich in protein, dietary fibre and low in fat. Several studies have indicated peptide hydrolysate from Lupin (LPH) have unique health benefits, Including lowering high blood pressure, high cholesterol, anti‐oxidative stress, antidiabetic and ant‐inflammation. Oxidative stress lead to chronic inflammation, prolonged chronic inflammation causes DNA damage, this is one of the several cancer causing pathways. Peptide hydrolysates from other legumes structurally similar to LPH has shown to alter several cancer causing and progression pathways such as inducing apoptosis, inhibiting metastasis and proliferation. Studies indicated that protein peptides derived from lupin reduced cancer cell migration by inhibiting MMP‐9 activity, However LPH’s modulatory effect on several other cellular mechanisms contribute to cancer cell development and growth have not been studied. This paper will examine the effect of peptide hydrolysate from lupin on cancer cells cellular mechanisms using SW480 colorectal cancer cell line. Using Cell‐cycle, Apo‐percentage and cell wound assays LPH’s effect on inducing cell‐cycle arrest, apoptosis and inhibition of metastasis will be studied respectively
Original languageEnglish
Pages139
Number of pages1
Publication statusPublished - 27 Aug 2019
Event69th Australasian Grain Science Conference - Rydges on Swanston, Melbourne, Australia
Duration: 27 Aug 201929 Aug 2019
Conference number: 69
https://www.ausgrainscience.org.au/faq-2/2019-conference-handbook-and-abstracts-2/

Conference

Conference69th Australasian Grain Science Conference
Abbreviated titleGrains: A global food resource
CountryAustralia
CityMelbourne
Period27/08/1929/08/19
Internet address

Fingerprint Dive into the research topics of 'Anti-cancer properties of Lupin Peptide Hydrolysate'. Together they form a unique fingerprint.

  • Cite this

    Melke, H., Chinkwo, K., Santhakumar, A., Francis, N., & Blanchard, C. (2019). Anti-cancer properties of Lupin Peptide Hydrolysate. 139. Poster session presented at 69th Australasian Grain Science Conference, Melbourne, Australia.