Abstract
Lupin seeds are rich in protein, dietary fibre and low in fat. Several studies have indicated peptide hydrolysate from Lupin (LPH) have unique health benefits, Including lowering high blood pressure, high cholesterol, anti‐oxidative stress, antidiabetic and ant‐inflammation. Oxidative stress lead to chronic inflammation, prolonged chronic inflammation causes DNA damage, this is one of the several cancer causing pathways. Peptide hydrolysates from other legumes structurally similar to LPH has shown to alter several cancer causing and progression pathways such as inducing apoptosis, inhibiting metastasis and proliferation. Studies indicated that protein peptides derived from lupin reduced cancer cell migration by inhibiting MMP‐9 activity, However LPH’s modulatory effect on several other cellular mechanisms contribute to cancer cell development and growth have not been studied. This paper will examine the effect of peptide hydrolysate from lupin on cancer cells cellular mechanisms using SW480 colorectal cancer cell line. Using Cell‐cycle, Apo‐percentage and cell wound assays LPH’s effect on inducing cell‐cycle arrest, apoptosis and inhibition of metastasis will be studied respectively
| Original language | English |
|---|---|
| Pages | 139 |
| Number of pages | 1 |
| Publication status | Published - 27 Aug 2019 |
| Event | 69th Australasian Grain Science Conference - Rydges on Swanston, Melbourne, Australia Duration: 27 Aug 2019 → 29 Aug 2019 Conference number: 69 https://www.ausgrainscience.org.au/faq-2/2019-conference-handbook-and-abstracts-2/ |
Conference
| Conference | 69th Australasian Grain Science Conference |
|---|---|
| Abbreviated title | Grains: A global food resource |
| Country/Territory | Australia |
| City | Melbourne |
| Period | 27/08/19 → 29/08/19 |
| Internet address |
