Antibiotic prophylaxis in third molar surgery, a prospective randomized double blind placebo controlled clinical trial using split mouth technique

Allauddin Siddiqi, J A Morkel, Sobia Zafar

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

The use of prophylactic antibiotics to reduce postoperative complications in third molar surgery remains controversial. The study was a prospective, randomized, double blind, placebo-controlled clinical trial. 100 patients were randomly assigned to two groups. Each patient acted as their own control using the split-mouth technique. Two unilateral impacted third molars were removed under antibiotic cover and the other two were removed without antibiotic cover. The first group received antibiotics on the first surgical visit. On the second surgical visit (after 3 weeks), placebo capsules were given or vice versa. The second group received antibiotics with continued therapy for 2 days on the first surgical visit and on the second surgical visit (after 3 weeks) placebo capsules were given or vice versa. Pain, swelling, infection, trismus and temperature were recorded on days 3, 7 and 14 after surgery. Of 380 impactions, 6 sockets (2%) became infected. There was no statistically significant difference in the infection rate, pain, swelling, trismus, and temperature between the two groups (p > 0.05). Results of the study showed that prophylactic antibiotics did not have a statistically significant effect on postoperative infections in third are removed in non-immunocompromised patients.
Original languageEnglish
Pages (from-to)107-114
Number of pages8
JournalInternational Journal of Oral and Maxillofacial Surgery
Volume39
Issue number2
DOIs
Publication statusPublished - Feb 2010

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