Antihepatotoxic and Antioxidant Activities of Methanol Extract and Isolated Compounds from Ficus chlamydocarpa

Jean Hubert Donfack, Christophe Colombe Fotso Simo, Bathelemy Ngameni, Angèle N. Tchana, Philip Kerr, Paola Vita Finzi, Giovanni Vidari, Silvana Giardina, Daniela Buonocore, Bonaventure T. Ngadjui, Paul F. Moundipa, Fulvio Marzatico

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Free radicals, in particular radical oxygen species (ROS), play an important role in the aetiology and pathogenesis of various diseases. Current research in many countries focuses on the use of local medicinal plants as a promising source of liverprotective agents. This paper describes the hepatoprotective effects of the methanol extract and four isolated compounds from Ficus chlamydocarpa on CCl4-induced liver damage, as well as the possible antioxidant mechanisms involved in this protection. The DPPH test, along with the ß-Carotene-Linoleic Acid Model System and Ferric-Reducing Antioxidant Power assays, as well as the inhibition of microsomal lipid peroxidation were used to measure radical-scavenging and antioxidantactivities. Pretreatment of rats with the methanol extract of F. chlamydocarpa before CCl4 administration, significantly prevented serum increase of hepatic enzyme markers, glutamate oxaloacetate transaminase (GOT) and glutamate pyruvatetransaminase (GPT), in a dose-dependent manner. The hepatoprotection was also associated with a significant enhancement inhepatic reduced glutathione (GSH) and a marked decrease of liver malondialdehyde (MDA). Among the four compounds 1-4,isolated from the methanol extract, '-amyrin acetate (1) and luteolin (4) showed a significant hepatoprotective activity, as indicated by their ability to prevent liver cell death and lactate dehydrogenase (LDH) leakage during CCl4 intoxication.
Original languageEnglish
Pages (from-to)1607-1612
Number of pages6
JournalNatural Product Communications
Volume5
Issue number10
Publication statusPublished - 2010

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