Abstract
Oxidative stress, inflammation, and endothelial dysfunction have been associated with the development of cardiovascular diseases. Rice bran (RB) derived phenolic extracts are recognised to have antioxidant and anti-inflammatory potential. This study aimed to evaluate if RB derived phenolic extracts could potentially modulate genes associated with antioxidant and anti-inflammatory pathways in human umbilical vein endothelial cells (HUVECs) under induced oxidative stress conditions. HUVECs were pre-treated with varying concentrations of RB phenolic extracts (25 – 250 µg/mL) and induced with oxidative stress environment. The expression of genes involved in the regulation of antioxidant and anti-inflammatory pathways was evaluated using quantitative real-time polymerase chain reaction. RB derived phenolic extracts downregulated the expression of ICAM-1, CD39, CD73, and NOX4 genes and up-regulated Nrf2, NQO1, HO1, and eNOS genes. The results support the hypothesis that RB derived phenolic extracts may potentially target genes associated with antioxidant and anti-inflammatory pathways in HUVECs induced with oxidative stress conditions.
| Original language | English |
|---|---|
| Publication status | Published - 27 Aug 2019 |
| Event | 69th Australasian Grain Science Conference - Rydges on Swanston, Melbourne, Australia Duration: 27 Aug 2019 → 29 Aug 2019 Conference number: 69 https://www.ausgrainscience.org.au/faq-2/2019-conference-handbook-and-abstracts-2/ |
Conference
| Conference | 69th Australasian Grain Science Conference |
|---|---|
| Abbreviated title | Grains: A global food resource |
| Country/Territory | Australia |
| City | Melbourne |
| Period | 27/08/19 → 29/08/19 |
| Internet address |