Antioxidant and anti-inflammatory potential of rice bran derived phenolic compounds in human umbilical vein endothelial cells

Research output: Other contribution to conferencePoster

Abstract

Oxidative stress, inflammation, and endothelial dysfunction have been associated with the development of cardiovascular diseases. Rice bran (RB) derived phenolic extracts are recognised to have antioxidant and anti-inflammatory potential. This study aimed to evaluate if RB derived phenolic extracts could potentially modulate genes associated with antioxidant and anti-inflammatory pathways in human umbilical vein endothelial cells (HUVECs) under induced oxidative stress conditions. HUVECs were pre-treated with varying concentrations of RB phenolic extracts (25 – 250 µg/mL) and induced with oxidative stress environment. The expression of genes involved in the regulation of antioxidant and anti-inflammatory pathways was evaluated using quantitative real-time polymerase chain reaction. RB derived phenolic extracts downregulated the expression of ICAM-1, CD39, CD73, and NOX4 genes and up-regulated Nrf2, NQO1, HO1, and eNOS genes. The results support the hypothesis that RB derived phenolic extracts may potentially target genes associated with antioxidant and anti-inflammatory pathways in HUVECs induced with oxidative stress conditions.
Original languageEnglish
Publication statusPublished - 27 Aug 2019
Event69th Australasian Grain Science Conference - Rydges on Swanston, Melbourne, Australia
Duration: 27 Aug 201929 Aug 2019
Conference number: 69
https://www.ausgrainscience.org.au/faq-2/2019-conference-handbook-and-abstracts-2/

Conference

Conference69th Australasian Grain Science Conference
Abbreviated titleGrains: A global food resource
CountryAustralia
CityMelbourne
Period27/08/1929/08/19
Internet address

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