Antioxidant and anti-inflammatory potential of rice bran derived phenolic compounds in human umbilical vein endothelial cells

Research output: Other contribution to conferencePoster

Abstract

Oxidative stress, inflammation, and endothelial dysfunction have been associated with the development of cardiovascular diseases. Rice bran (RB) derived phenolic extracts are recognised to have antioxidant and anti-inflammatory potential. This study aimed to evaluate if RB derived phenolic extracts could potentially modulate genes associated with antioxidant and anti-inflammatory pathways in human umbilical vein endothelial cells (HUVECs) under induced oxidative stress conditions. HUVECs were pre-treated with varying concentrations of RB phenolic extracts (25 – 250 µg/mL) and induced with oxidative stress environment. The expression of genes involved in the regulation of antioxidant and anti-inflammatory pathways was evaluated using quantitative real-time polymerase chain reaction. RB derived phenolic extracts downregulated the expression of ICAM-1, CD39, CD73, and NOX4 genes and up-regulated Nrf2, NQO1, HO1, and eNOS genes. The results support the hypothesis that RB derived phenolic extracts may potentially target genes associated with antioxidant and anti-inflammatory pathways in HUVECs induced with oxidative stress conditions.
Original languageEnglish
Publication statusPublished - 27 Aug 2019
Event2019 Australasian Grain Science Conference: Grains: A Global Food Resource - Rydges on Swanston, Melbourne, Australia
Duration: 27 Aug 201929 Aug 2019
Conference number: 69
https://www.ausgrainscience.org.au/faq-2/2019-conference-handbook-and-abstracts-2/

Conference

Conference2019 Australasian Grain Science Conference
CountryAustralia
CityMelbourne
Period27/08/1929/08/19
Internet address

Fingerprint

Human Umbilical Vein Endothelial Cells
Anti-Inflammatory Agents
Antioxidants
Oxidative Stress
Genes
Intercellular Adhesion Molecule-1
Real-Time Polymerase Chain Reaction
Cardiovascular Diseases
Down-Regulation
Oryza
Inflammation
Gene Expression

Cite this

@conference{e099871bb8c94aa0aa9df8be9853f1dd,
title = "Antioxidant and anti-inflammatory potential of rice bran derived phenolic compounds in human umbilical vein endothelial cells",
abstract = "Oxidative stress, inflammation, and endothelial dysfunction have been associated with the development of cardiovascular diseases. Rice bran (RB) derived phenolic extracts are recognised to have antioxidant and anti-inflammatory potential. This study aimed to evaluate if RB derived phenolic extracts could potentially modulate genes associated with antioxidant and anti-inflammatory pathways in human umbilical vein endothelial cells (HUVECs) under induced oxidative stress conditions. HUVECs were pre-treated with varying concentrations of RB phenolic extracts (25 – 250 µg/mL) and induced with oxidative stress environment. The expression of genes involved in the regulation of antioxidant and anti-inflammatory pathways was evaluated using quantitative real-time polymerase chain reaction. RB derived phenolic extracts downregulated the expression of ICAM-1, CD39, CD73, and NOX4 genes and up-regulated Nrf2, NQO1, HO1, and eNOS genes. The results support the hypothesis that RB derived phenolic extracts may potentially target genes associated with antioxidant and anti-inflammatory pathways in HUVECs induced with oxidative stress conditions.",
author = "Nancy Saji and Nidhish Francis and Lachlan Schwarz and Christopher Blanchard and Abishek Santhakumar",
year = "2019",
month = "8",
day = "27",
language = "English",
note = "2019 Australasian Grain Science Conference : Grains: A Global Food Resource ; Conference date: 27-08-2019 Through 29-08-2019",
url = "https://www.ausgrainscience.org.au/faq-2/2019-conference-handbook-and-abstracts-2/",

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Antioxidant and anti-inflammatory potential of rice bran derived phenolic compounds in human umbilical vein endothelial cells. / Saji, Nancy; Francis, Nidhish; Schwarz, Lachlan; Blanchard, Christopher; Santhakumar, Abishek.

2019. Poster session presented at 2019 Australasian Grain Science Conference, Melbourne, Australia.

Research output: Other contribution to conferencePoster

TY - CONF

T1 - Antioxidant and anti-inflammatory potential of rice bran derived phenolic compounds in human umbilical vein endothelial cells

AU - Saji, Nancy

AU - Francis, Nidhish

AU - Schwarz, Lachlan

AU - Blanchard, Christopher

AU - Santhakumar, Abishek

PY - 2019/8/27

Y1 - 2019/8/27

N2 - Oxidative stress, inflammation, and endothelial dysfunction have been associated with the development of cardiovascular diseases. Rice bran (RB) derived phenolic extracts are recognised to have antioxidant and anti-inflammatory potential. This study aimed to evaluate if RB derived phenolic extracts could potentially modulate genes associated with antioxidant and anti-inflammatory pathways in human umbilical vein endothelial cells (HUVECs) under induced oxidative stress conditions. HUVECs were pre-treated with varying concentrations of RB phenolic extracts (25 – 250 µg/mL) and induced with oxidative stress environment. The expression of genes involved in the regulation of antioxidant and anti-inflammatory pathways was evaluated using quantitative real-time polymerase chain reaction. RB derived phenolic extracts downregulated the expression of ICAM-1, CD39, CD73, and NOX4 genes and up-regulated Nrf2, NQO1, HO1, and eNOS genes. The results support the hypothesis that RB derived phenolic extracts may potentially target genes associated with antioxidant and anti-inflammatory pathways in HUVECs induced with oxidative stress conditions.

AB - Oxidative stress, inflammation, and endothelial dysfunction have been associated with the development of cardiovascular diseases. Rice bran (RB) derived phenolic extracts are recognised to have antioxidant and anti-inflammatory potential. This study aimed to evaluate if RB derived phenolic extracts could potentially modulate genes associated with antioxidant and anti-inflammatory pathways in human umbilical vein endothelial cells (HUVECs) under induced oxidative stress conditions. HUVECs were pre-treated with varying concentrations of RB phenolic extracts (25 – 250 µg/mL) and induced with oxidative stress environment. The expression of genes involved in the regulation of antioxidant and anti-inflammatory pathways was evaluated using quantitative real-time polymerase chain reaction. RB derived phenolic extracts downregulated the expression of ICAM-1, CD39, CD73, and NOX4 genes and up-regulated Nrf2, NQO1, HO1, and eNOS genes. The results support the hypothesis that RB derived phenolic extracts may potentially target genes associated with antioxidant and anti-inflammatory pathways in HUVECs induced with oxidative stress conditions.

M3 - Poster

ER -