Antioxidant and antidiarrheal activity of the methanolic extract of Microcos Paniculata roots

M. A. Aziz, M. I. Akter, D. N. Roy, K. Mazumder, M. S. Rana

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Abstract

Microcos paniculata is traditionally used for treating diarrhea, hepatitis, wounds, colds, fever, dyspepsia and heat stroke. Objective. To investigate the antioxidant and antidiarrheal activity of the methanolic extract of M. paniculata roots (RME). Antioxidant and antidiarrheal activity of RME were evaluated by different tests such as total antioxidant capacity (TAC), DPPH free radical scavenging assay (DPPHFRSA), nitric oxide scavenging capacity assay (NOSCA), lipid peroxidation by thiobarbituric acid assay (LPTAA), reducing capacity assessment (RCA), cupric reducing antioxidant capacity (CRAC), castor oil and MgSO 4 induced diarrheal tests. The total phenols and flavonoids contents and TAC were 182.78 ± 0.12 mg/g RME (in gallic acid equivalent) and 43.5 ± 0.32 mg/g RME (in quercetin equivalent) and 40.83 ± 0.69 mg/g RME (in ascorbic acid equivalent) respectively. The IC 50 values of the RME in DPPHFRSA, NOSCA and LPTAA were 158.47 ± 2.66 μg/mL, 157.91 ± 4.56 μg/mL and 148.29 ± 6.48 μg/mL correspondingly. Concentration dependent reducing power was observed in RCA and CRAC respectively. Moreover, RME 400 mg/kg produced 68.10±16.99 % and 55.83±21.95 % inhibition of diarrhea in antidiarrheal models. Study results indicate that M. paniculata may provide a source of plant compounds with antioxidant and antidiarrheal activity.

Original languageEnglish
Pages (from-to)31-48
Number of pages18
JournalPharmacologyonline
Volume2
Publication statusPublished - 30 Aug 2018

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