Antiviral assessment of honeybee (Apis mellifera L.) venom

Sang-Mi Han, Se Gun Kim, Young-Hyo Kim, Hong Min Choi, Hyo Jung Moon, Soon Ok Woo, Sokcheon Pak

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Abstract

The poultry industry has long been challenged by avian
influenza which causes significant economic loss due to decreased egg
production and quality. In addition, the notable ability of influenza viruses
to develop resistance to conventional antibiotics is one of the biggest tasks
that the industry currently faces. Attempts have been made to treat this
bird flu with multiple approaches, but effective natural solutions remain
elusive. Bee venom (BV) is used for the treatment of various human
diseases due to its known anti‑inflammatory and antibacterial properties.
Recent studies suggest that antimicrobial peptides discovered in BV may
be utilized as tools for the design of structurally novel antiviral agents
effective against influenza viruses. Materials and Methods: In the present
study, we purified BV containing 63.9% ± 5.4% melittin, 10.9% ± 1.6%
phospholipase A2, and 2.3% ± 0.3% apamin. BV was evaluated in vitro
for its ability to inhibit the binding of H9N2 to the chicken red blood cells.
Results: We found that anti‑influenza activity of BV is equivalent to that
of positive control. However, we observed the neutralization of H9N2 by
BV as compared to the virus only group without BV. The hypothesized
anti‑influenza property of BV was further examined in chicken influenza
infection model. The administration of BV through intranasal route resulted
in no significant antiviral effect in chickens. Conclusion: This study does
not support our hypothesis that BV can reduce the viral activity in chickens.
Original languageEnglish
Pages (from-to)382-385
Number of pages4
JournalPharmacognosy Magazine
Volume16
Issue number69
Publication statusPublished - 15 Jun 2020

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