Are Antiphospholipid Antibodies a Surrogate Risk Factor for Thrombosis in Sepsis?

Jecko Thachil, Emmanuel J Favaloro, Giuseppe Lippi

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Antiphospholipid syndrome (APS) is a hypercoagulable state caused by antiphospholipid antibodies (aPL). APS clinically manifests with arterial or venous or microvascular thrombi and/or pregnancy complications. It is well-known that the development of aPL can be a transient phenomenon and thus the current diagnostic criterion for APS requires repeat laboratory testing several weeks apart before a definitive diagnosis is made. However, transient presence of aPL may also be pathogenic. In this article, we attempt to give historical and clinical evidence for the importance of these antibodies, even when transient, and call for further research into mechanisms by which these antibodies may promote thrombosis and pregnancy morbidities.

Original languageEnglish
JournalSeminars in Thrombosis and Hemostasis
Early online date28 Jul 2023
DOIs
Publication statusE-pub ahead of print - 28 Jul 2023

Fingerprint

Dive into the research topics of 'Are Antiphospholipid Antibodies a Surrogate Risk Factor for Thrombosis in Sepsis?'. Together they form a unique fingerprint.

Cite this