Artemisinins inhibit Trypanosoma cruzi and Trypanosoma brucei rhodesiense in vitro growth

Yuliya V. Mishina; Sanjeev Krishna; Richard K. Haynes; John C. Meade

doi:10.1128/AAC.01544-06

Artemisinins inhibit Trypanosoma cruzi and Trypanosoma brucei rhodesiense in vitro growth

Yuliya V. Mishina, Sanjeev Krishna, Richard K. Haynes, John C. Meade

Research output: Contribution to journal › Article › peer-review

119 Citations (Scopus)

Abstract

Artemisinin compounds inhibit in vitro growth of cultured Trypanosoma cruzi and Trypanosoma brucei rhodesiense at concentrations in the low micromolar range. Artemisinin also inhibits calcium-dependent ATPase activity in T. cruzi membranes, suggesting a mode of action via membrane pumps. Artemisinins merit further investigation as chemotherapeutic options for these pathogens.

Original language	English
Pages (from-to)	1852-1854
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	51
Issue number	5
DOIs	https://doi.org/10.1128/AAC.01544-06
Publication status	Published - May 2007

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abstract = "Artemisinin compounds inhibit in vitro growth of cultured Trypanosoma cruzi and Trypanosoma brucei rhodesiense at concentrations in the low micromolar range. Artemisinin also inhibits calcium-dependent ATPase activity in T. cruzi membranes, suggesting a mode of action via membrane pumps. Artemisinins merit further investigation as chemotherapeutic options for these pathogens.",

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Artemisinins inhibit Trypanosoma cruzi and Trypanosoma brucei rhodesiense in vitro growth

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