@article{fd5060e303a140c1bb520dd62e51d2a6,
title = "Artemisinins: Mechanisms of action and potential for resistance",
abstract = "Artemisinins form the most important class of antimalarial currently available, particularly because they are effective against parasites resistant to almost all the other classes. Their mechanism of action is controversial. Some aspects of this controversy are reviewed here. Whilst there is no clinical resistance yet identified to artemisinins, the potential to examine the relationship between polymorphisms in PfATP6 (a target of artemisinins) in multidrug resistant isolates of Plasmodium falciparum, is also discussed.",
keywords = "Artemisinin, Endoperoxides, Malaria, Plasmodium falciparum",
author = "Sanjeev Krishna and Uhlemann, {Anne Catrin} and Haynes, {Richard K.}",
note = "Funding Information: We would like to thank Dr. U. Eckstein for help with the immunofluorescence. Some studies were funded by The Wellcome Trust (Grant no. 066201). Studies at HKUST are funded through the Open Laboratory of Chirotechnology of the Institute of Molecular Technology for Drug Discovery and Synthesis with financial support from the Government of the HKSAR University Grants Committee Areas of Excellence Fund, Project No. AoE P/10-01, and University Grants Council, Grant No. HKUST 6091/02P.",
year = "2004",
doi = "10.1016/j.drup.2004.07.001",
language = "English",
volume = "7",
pages = "233--244",
journal = "Drug Resistance Updates",
issn = "1368-7646",
publisher = "Churchill Livingstone",
number = "4-5",
}
