Artemisone - A highly active antimalarial drug of the artemisinin class

Richard K. Haynes; Burkhard Fugmann; Jörg Stetter; Karl Rieckmann; Hans Dietrich Heilmann; Ho Wai Chan; Man Ki Cheung; Wai Lun Lam; Ho Ning Wong; Simon L. Croft; Livia Vivas; Lauren Rattray; Lindsay Stewart; Wallace Peters; Brian L. Robinson; Michael D. Edstein; Barbara Kotecka; Dennis E. Kyle; Bernhard Beckermann; Michael Gerisch; Martin Radtke; Gabriele Schmuck; Wolfram Steinke; Ute Wollborn; Karl Schmeer; Axel Römer

doi:10.1002/anie.200503071

Artemisone - A highly active antimalarial drug of the artemisinin class

Richard K. Haynes, Burkhard Fugmann, Jörg Stetter, Karl Rieckmann, Hans Dietrich Heilmann, Ho Wai Chan, Man Ki Cheung, Wai Lun Lam, Ho Ning Wong, Simon L. Croft, Livia Vivas, Lauren Rattray, Lindsay Stewart, Wallace Peters, Brian L. Robinson, Michael D. Edstein, Barbara Kotecka, Dennis E. Kyle, Bernhard Beckermann, Michael GerischMartin Radtke, Gabriele Schmuck, Wolfram Steinke, Ute Wollborn, Karl Schmeer, Axel Römer

Research output: Contribution to journal › Article › peer-review

241 Citations (Scopus)

Abstract

Artemisinin - the next generation: Efficacies of artemisone against the malaria parasite are substantially greater than those of the current artemisinin "gold standard", artesunate. Also, in contrast to most current artemisinins it displays low lipophilicity and negligible neuro- and cytotoxicity in in vitro and in vivo assays. Thus, the drug offers promise for use in artemisinin-based combination therapy. (Chemical Equation Presented).

Original language	English
Pages (from-to)	2082-2088
Number of pages	7
Journal	Angewandte Chemie - International Edition
Volume	45
Issue number	13
DOIs	https://doi.org/10.1002/anie.200503071
Publication status	Published - 20 Mar 2006

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/anie.200503071

Cite this

Haynes, R. K., Fugmann, B., Stetter, J., Rieckmann, K., Heilmann, H. D., Chan, H. W., Cheung, M. K., Lam, W. L., Wong, H. N., Croft, S. L., Vivas, L., Rattray, L., Stewart, L., Peters, W., Robinson, B. L., Edstein, M. D., Kotecka, B., Kyle, D. E., Beckermann, B., ... Römer, A. (2006). Artemisone - A highly active antimalarial drug of the artemisinin class. Angewandte Chemie - International Edition, 45(13), 2082-2088. https://doi.org/10.1002/anie.200503071

@article{6fed9c3b244f4e548ebdd147b9375d47,

title = "Artemisone - A highly active antimalarial drug of the artemisinin class",

abstract = "Artemisinin - the next generation: Efficacies of artemisone against the malaria parasite are substantially greater than those of the current artemisinin {"}gold standard{"}, artesunate. Also, in contrast to most current artemisinins it displays low lipophilicity and negligible neuro- and cytotoxicity in in vitro and in vivo assays. Thus, the drug offers promise for use in artemisinin-based combination therapy. (Chemical Equation Presented).",

keywords = "Antimalarial agents, Artemisinins, Medicinal chemistry, Metabolism, Neurotoxicity",

author = "Haynes, {Richard K.} and Burkhard Fugmann and J{\"o}rg Stetter and Karl Rieckmann and Heilmann, {Hans Dietrich} and Chan, {Ho Wai} and Cheung, {Man Ki} and Lam, {Wai Lun} and Wong, {Ho Ning} and Croft, {Simon L.} and Livia Vivas and Lauren Rattray and Lindsay Stewart and Wallace Peters and Robinson, {Brian L.} and Edstein, {Michael D.} and Barbara Kotecka and Kyle, {Dennis E.} and Bernhard Beckermann and Michael Gerisch and Martin Radtke and Gabriele Schmuck and Wolfram Steinke and Ute Wollborn and Karl Schmeer and Axel R{\"o}mer",

year = "2006",

month = mar,

day = "20",

doi = "10.1002/anie.200503071",

language = "English",

volume = "45",

pages = "2082--2088",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley & Sons",

number = "13",

}

Haynes, RK, Fugmann, B, Stetter, J, Rieckmann, K, Heilmann, HD, Chan, HW, Cheung, MK, Lam, WL, Wong, HN, Croft, SL, Vivas, L, Rattray, L, Stewart, L, Peters, W, Robinson, BL, Edstein, MD, Kotecka, B, Kyle, DE, Beckermann, B, Gerisch, M, Radtke, M, Schmuck, G, Steinke, W, Wollborn, U, Schmeer, K & Römer, A 2006, 'Artemisone - A highly active antimalarial drug of the artemisinin class', Angewandte Chemie - International Edition, vol. 45, no. 13, pp. 2082-2088. https://doi.org/10.1002/anie.200503071

TY - JOUR

T1 - Artemisone - A highly active antimalarial drug of the artemisinin class

AU - Haynes, Richard K.

AU - Fugmann, Burkhard

AU - Stetter, Jörg

AU - Rieckmann, Karl

AU - Heilmann, Hans Dietrich

AU - Chan, Ho Wai

AU - Cheung, Man Ki

AU - Lam, Wai Lun

AU - Wong, Ho Ning

AU - Croft, Simon L.

AU - Vivas, Livia

AU - Rattray, Lauren

AU - Stewart, Lindsay

AU - Peters, Wallace

AU - Robinson, Brian L.

AU - Edstein, Michael D.

AU - Kotecka, Barbara

AU - Kyle, Dennis E.

AU - Beckermann, Bernhard

AU - Gerisch, Michael

AU - Radtke, Martin

AU - Schmuck, Gabriele

AU - Steinke, Wolfram

AU - Wollborn, Ute

AU - Schmeer, Karl

AU - Römer, Axel

PY - 2006/3/20

Y1 - 2006/3/20

N2 - Artemisinin - the next generation: Efficacies of artemisone against the malaria parasite are substantially greater than those of the current artemisinin "gold standard", artesunate. Also, in contrast to most current artemisinins it displays low lipophilicity and negligible neuro- and cytotoxicity in in vitro and in vivo assays. Thus, the drug offers promise for use in artemisinin-based combination therapy. (Chemical Equation Presented).

AB - Artemisinin - the next generation: Efficacies of artemisone against the malaria parasite are substantially greater than those of the current artemisinin "gold standard", artesunate. Also, in contrast to most current artemisinins it displays low lipophilicity and negligible neuro- and cytotoxicity in in vitro and in vivo assays. Thus, the drug offers promise for use in artemisinin-based combination therapy. (Chemical Equation Presented).

KW - Antimalarial agents

KW - Artemisinins

KW - Medicinal chemistry

KW - Metabolism

KW - Neurotoxicity

UR - http://www.scopus.com/inward/record.url?scp=33745975677&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745975677&partnerID=8YFLogxK

U2 - 10.1002/anie.200503071

DO - 10.1002/anie.200503071

M3 - Article

C2 - 16444785

AN - SCOPUS:33745975677

SN - 1433-7851

VL - 45

SP - 2082

EP - 2088

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 13

ER -

Artemisone - A highly active antimalarial drug of the artemisinin class

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this