Aryl Sulfonohydrazides

Anne K. Voss (Inventor), Jonathan B. Baell (Inventor), Nghi Nguyen (Inventor), David Leaver (Inventor), Benjamin Cleary (Inventor), H. Rachel Lagiakos (Inventor), Bilal N. Sheikh (Inventor), Timothy Thomas (Inventor)

Research output: Patent

Abstract

Compound of formula (I) wherein A is selected from (i), where RF1 is H or F; (ii); (iii) a N-containing Cll heteroaryl group; and B is (B), where X1 is either CRF2 or N, where RF2 is H or F; X2 is either CR3 or N, where R3 is selected from H, Me, Cl, F OMe; X3 is either CH or N; X4 is either CRF3 or N, where RF3 is H or F; where only one or two of X1, X2, X3 and X4 may be N; and R4 is selected from I, optionally substituted phenyl, optionally substituted C5-6 heteroaryl; optionally substituted C1-6 alkyl and optionally substituted C1-6 alkoxy, which are useful in the treatment of a condition ameliorated by the inhibition of MOZ.
Original languageEnglish
Patent numberWO2016198507
IPCA61K31/145 (2006.01),A61K 31/341 (2006.01),A61K31/38 (2006.01),A61K31/395 (2006.01),C07D 213/87 (2006.01),C07D 231/12 (2006.01),C07D 231/16 (2006.01),C07D 333/24 (2006.01),C07C 311/49 (2006.01),C07D 237/08 (2006.01),C07D 249/06 (2006.01),C07D 271/06 (2006.01),C07D 271/10 (2006.01),C07D 277/30 (2006.01),C07D 213/54 (2006.01),C07D 307/54 (2006.01),A61P 35/02 (2006.01)
Priority date09/06/15
Filing date09/06/16
Publication statusPublished - 15 Dec 2016
Externally publishedYes

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