Jojoba is a relatively new crop that is adapted to hot, dry climates. The crop is grown for its seed, which contains a wax with a high melting point. This wax is used in a variety of products, including lubricants, pharmaceuticals, and cosmetics. Various aspects of the crop agronomy and management are reviewed, including a botanical description, propagation from seed and cuttings, the genetics of the plant and wax production, and the various physical characteristics that affect the crop's growth and yield, such as soil, water, fertilizer requirements, salt, pH, temperature tolerance, and mycorrhizal status of the crop. Last, the pests (insects, arthropods, and diseases) of jojoba are reviewed. This chapter is intended to provide scientists and managers with a reference on the agronomy and management of jojoba.