Assessing circovirus gene flow in multiple spill-over events

Shubhagata Das, Kate Smith, Subir Sarker, Andrew Peters, Katherine Adriaanse, Paul Eden, Seyed Ghorashi, Jade Forwood, Shane Raidal

Research output: Contribution to journalArticle

Abstract

The establishment of viral pathogens in new host environments following spillover events probably requires adaptive changes within both the new host and pathogen. After many generations, signals for ancient cross-species transmission may become lost and a strictly host-adapted phylogeny may mimic true co-divergence while the virus may retain an inherent ability to jump host species. The mechanistic basis for such processes remains poorly understood. To study the dynamics of virus–host co-divergence and the arbitrary chances of spillover in various reservoir hosts with equal ecological opportunity, we examined structural constraints of capsid protein in extant populations of Beak and feather disease virus (BFDV) during known spillover events. By assessing reservoir-based genotype stratification, we identified co-divergence defying signatures in the evolution BFDV which highlighted primordial processes of cryptic host adaptation and competing forces of host co-divergence and cross-species transmission. We demonstrate that, despite extensive surface plasticity gathered over a longer span of evolution, structural constraints of the capsid protein allow opportunistic host switching in host-adapted populations. This study provides new insights into how small populations of endangered psittacine species may face multidirectional forces of infection from reservoirs with apparently co-diverging genotypes.
Original languageEnglish
Pages (from-to)1-13
Number of pages13
JournalVirus Genes
DOIs
Publication statusE-pub ahead of print - 28 Aug 2019

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Circovirus
Gene Flow
Capsid Proteins
Psittaciformes
Genotype
Population
Endangered Species
Phylogeny
Viruses
Infection

Cite this

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title = "Assessing circovirus gene flow in multiple spill-over events",
abstract = "The establishment of viral pathogens in new host environments following spillover events probably requires adaptive changes within both the new host and pathogen. After many generations, signals for ancient cross-species transmission may become lost and a strictly host-adapted phylogeny may mimic true co-divergence while the virus may retain an inherent ability to jump host species. The mechanistic basis for such processes remains poorly understood. To study the dynamics of virus–host co-divergence and the arbitrary chances of spillover in various reservoir hosts with equal ecological opportunity, we examined structural constraints of capsid protein in extant populations of Beak and feather disease virus (BFDV) during known spillover events. By assessing reservoir-based genotype stratification, we identified co-divergence defying signatures in the evolution BFDV which highlighted primordial processes of cryptic host adaptation and competing forces of host co-divergence and cross-species transmission. We demonstrate that, despite extensive surface plasticity gathered over a longer span of evolution, structural constraints of the capsid protein allow opportunistic host switching in host-adapted populations. This study provides new insights into how small populations of endangered psittacine species may face multidirectional forces of infection from reservoirs with apparently co-diverging genotypes.",
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Assessing circovirus gene flow in multiple spill-over events. / Das, Shubhagata; Smith, Kate; Sarker, Subir; Peters, Andrew; Adriaanse, Katherine; Eden, Paul; Ghorashi, Seyed; Forwood, Jade; Raidal, Shane.

In: Virus Genes, 28.08.2019, p. 1-13.

Research output: Contribution to journalArticle

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